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Description
Pacific Blue Mouse Anti-Rat CD45 Antibody (S-R591)Product Specification Host Mouse Antigen CD45 Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); T200; Ptprc Location Cell membrane, Synapse Accession P04157 Clone Number S R591 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Rt Positive Sample Wistar Rat splenocytes Purification Protein G Concentration 0. 05mg ml Conjugation Pacific Blue Physical Appearance Liquid Storage Buffer PBS, 25%
Product Specification
| Host | Mouse |
| Antigen | CD45 |
| Synonyms | Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); T200; Ptprc |
| Location | Cell membrane, Synapse |
| Accession | P04157 |
| Clone Number | S-R591 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | Wistar Rat splenocytes |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Pacific Blue |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Rt |
Background
CD45, also known as protein tyrosine phosphatase receptor type C (PTPRC) or leukocyte common antigen, is a transmembrane glycoprotein expressed on nearly all hematopoietic cells and plays a crucial role in the regulation of T and B cell antigen receptor-mediated activation. It is a type 1 transmembrane protein tyrosine phosphatase (PTPase) that is involved in the activation, development, tolerance, and survival of T and B-lymphocytes. CD45 is essential for the initiation of T cell receptor (TCR) signaling and modulates cytokine and chemokine production and signaling. It also negatively regulates monocytic cell differentiation and FLT3 signaling in vivo. The protein is involved in the nuclear apoptosis process and is vital for chromatin condensation and DNA fragmentation. Furthermore, CD45 is implicated in the interaction between T cells and macrophages and has been studied as a therapeutic target for immune diseases, including autoimmunity and organ transplantation. Disruption of the equilibrium between protein tyrosine kinase and phosphatase activity, which includes CD45, can result in immunodeficiency, autoimmunity, or malignancy.
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