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Description
Phospho-Histone H3 (Ser10) Recombinant Rabbit mAb (S-960-58)Product Specification Host Rabbit Antigen Phospho Histone H3 (Ser10) Synonyms H3S10P Immunogen Synthetic Peptide Location Nucleus Accession P68431 Clone Number S 960 58 Antibody Type Recombinant mAb Isotype IgG Application WB, ChIP Reactivity Hu, Ms, Rt Predicted Reactivity Ar, Bv, C. el, Dr, Hm, Or, Xe, Ys Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA,
Product Specification
| Host | Rabbit |
| Antigen | Phospho-Histone H3 (Ser10) |
| Synonyms | H3S10P |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P68431 |
| Clone Number | S-960-58 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ChIP |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Ar, Bv, C.el, Dr, Hm, Or, Xe, Ys |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:10000 | |
| WB | 1:20000 | Hu, Ms, Rt |
| ChIP | 1:20-1:50 | Hu, Ms, Rt |
Background
Phospho-Histone H3 (Ser10) is a critical epigenetic marker associated with chromosome condensation and mitotic progression. This phosphorylation event typically occurs during the G2 to M phase transition and is essential for chromatin condensation, making it a specific indicator of mitotic cells. It is regulated by kinases such as Aurora B and plays a significant role in mitotic chromosome condensation and decondensation. Additionally, H3 Ser10 phosphorylation has been implicated in transcriptional regulation and early gene expression, and its dysregulation has been linked to neoplastic cell transformation and cancer.
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