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Description
Histone H3 (citrulline R2 + R8 + R17) Recombinant Rabbit mAb (S-1733-17)Product Specification Host Rabbit Antigen Histone H3 (citrulline R2 + R8 + R17) Synonyms Histone H3. 1; Histone H3 a; Histone H3 b; Histone H3 c; Histone H3 d; Histone H3 f Immunogen Synthetic Peptide Location Nucleus Accession P68431 Clone Number S 1733 17 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | Histone H3 (citrulline R2 + R8 + R17) |
| Synonyms | Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P68431 |
| Clone Number | S-1733-17 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000 | Hu |
Background
Histone H3 is a core component of the nucleosome, the fundamental unit of chromatin, which plays a crucial role in organizing genomic DNA within the eukaryotic nucleus. The citrullination of Histone H3 at arginine residues R2, R8, and R17 is a specific post-translational modification catalyzed by peptidyl arginine deiminase 4 (PAD4). This modification prevents methylation of these residues by protein-arginine methyltransferase 4 (PRMT4) and is associated with transcriptional repression. Citrullinated Histone H3 is also a key component of neutrophil extracellular traps (NETs) and acts as an autoantigen, contributing to the production of anti-citrullinated protein antibodies in various diseases, including sepsis, multiple sclerosis, rheumatoid arthritis, and multiple myeloma.
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