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Description
SLAMF7/CRACC/CD319 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms SLAMF7, CD319, CS1, CRACC, 19A, FOAP 12 Accession XP_005541294. 2 Amino Acid Sequence Ser23 Met226, with C terminal 10*His SGSVKELVGSIGGAVTFPLKSEVKQVDSIVWTFNTTTLVTIQPEGGPMIVTQNRNKERVDFPDGGYSLKLSKLKKNDSGIYNVEIYSSSLQDPFTRKYVLRVYEHLSKPKVTMGLQSNKNGTCVTNLTCHMEHGEEDVIYTWKALGQAVNESHNGSILPISWRWGESDMTFICTVRNPVSSNSSSPILARKLCEGAADDSDSSMGGGSGGGSHHHHHHHHHH Expression System HEK293 Molecular Weight 35 45kDa Purity
Product Specification
| Species | Cynomolgus |
| Synonyms | SLAMF7, CD319, CS1, CRACC, 19A, FOAP-12 |
| Accession | XP_005541294.2 |
| Amino Acid Sequence | Ser23-Met226, with C-terminal 10*His SGSVKELVGSIGGAVTFPLKSEVKQVDSIVWTFNTTTLVTIQPEGGPMIVTQNRNKERVDFPDGGYSLKLSKLKKNDSGIYNVEIYSSSLQDPFTRKYVLRVYEHLSKPKVTMGLQSNKNGTCVTNLTCHMEHGEEDVIYTWKALGQAVNESHNGSILPISWRWGESDMTFICTVRNPVSSNSSSPILARKLCEGAADDSDSSMGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 35-45kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Lee J K. et al. (2004) Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. Eur J Immunol. 34(10): 2791-2799. 2、Tassi I. et al. (2005) The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. J Immunol. 175(12): 7996-8002. 3、Lee J K. et al. (2007) CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. J Immunol. 179(7): 4672-4678. 4、Cruz-Munoz M E. et al. (2009) Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 10(3): 297-305. |
Background
SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. Mature mouse CRACC consists of a 202 amino acid (aa) extracellular domain (ECD) with one Ig-like V-set domain and one Ig-like C2-set domain, a 21 aa transmembrane segment, and an 88 aa cytoplasmic domain with two immunoreceptor tyrosine-based switch motifs ITSMs. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Mediates natural killer (NK) cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on the adapter SH2D1B. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function.
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★★★★★ 3
The book itself is good. The content may be awkward or detailed in ...
Format: Paperback
The book itself is good. The content may be awkward or detailed in a way that makes reading tedious and a bit less enjoyable than what likw.
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Reviewed in the United States on April 28, 2016
★★★★★ 5
Nursing school book that helps
Format: Paperback
I use this book for nursing school :0.
The book covers a broad range of topics including cardiovascular diseases, respiratory conditions, diabetes, mental health, and much more. Each chapter is written by experts in the field, providing a high level of expertise and insight into best practices for managing various medical conditions.
One of the things I appreciate about this book is the clear and concise writing style. The guidelines are presented in a format that is easy to understand and follow, making it an ideal resource for busy practitioners. Additionally, the authors have included helpful algorithms and decision trees to aid in the management of complex cases.
Another strength of this book is the emphasis on evidence-based medicine. The guidelines are based on the latest research and are regularly updated to reflect new developments in the field. This ensures that healthcare professionals can provide the most effective and appropriate care for their patients.
Overall, I highly recommend Clinical Guidelines in Primary Care for healthcare professionals working in primary care settings. It is a comprehensive and practical guide that provides evidence-based recommendations for the diagnosis and management of a wide range of medical conditions.
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Reviewed in the United States on March 19, 2023
★★★★★ 5
Great Resource
Format: Paperback
As a resource for NP school (and even after, I'm sure), this book is fantastic. I recommend it to anyone asking if it's worth it. I, however, refer them to a different site than Amazon as it is cheaper straight from the publisher. Significantly so. A hundred dollars difference doesn't quite justify the next day or 2-day delivery.
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Reviewed in the United States on March 2, 2025
★★★★★ 5
So good for soap notes!
Format: Paperback
I wish I could have gotten this sooner when we had to write soap notes. It explains the illness, symptoms, tests, treatments, referrals and follow ups. I got it used and it came in great condition. Would definitely buy again!
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Reviewed in the United States on July 12, 2024
★★★★★ 5
Bible!
Format: Paperback
This book has been my life line with school. Freaking amazing and worth every penny.
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Reviewed in the United States on February 22, 2024