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Description
Human sFlt-1, His tagProduct Specification Species Human Synonyms Soluble fms like tyrosine kinase 1 Accession P17948 2 Amino Acid Sequence Protein sequence(P17948 2, Ser27 His687, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | Soluble fms-like tyrosine kinase 1 |
| Accession | P17948-2 |
| Amino Acid Sequence |
Protein sequence(P17948-2, Ser27-His687, with C-10*His)
|
| Expression System | HEK293 |
| Molecular Weight | Theoretical: 76.4kDa Actual: 100kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage |
|
Background
Soluble fms-like tyrosine kinase-1 (sFlt-1 or sVEGFR-1) is a tyrosine kinase protein with antiangiogenic properties. A non-membrane associated splice variant of VEGF receptor 1 (Flt-1), sFlt-1 binds the angiogenic factors VEGF (vascular endothelial growth factor) and PlGF (placental growth factor), reducing blood vessel growth through reduction of free VEGF and PlGF concentrations. In humans, sFlt-1 is important in the regulation of blood vessel formation in diverse tissues, including the kidneys, cornea, and uterus. Abnormally high levels of sFlt-1 have been implicated in the pathogenesis of preeclampsia.
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