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Description
LYVE1 Recombinant Rabbit mAb (S-3786-26)Product Specification Host Rabbit Antigen LYVE1 Synonyms Lymphatic vessel endothelial hyaluronic acid receptor 1; Cell surface retention sequence binding protein 1 (CRSBP 1); Extracellular link domain containing protein 1; Hyaluronic acid receptor; CRSBP1; HAR; XLKD1 Immunogen Recombinant Protein Location Cell membrane Accession Q9Y5Y7 Clone Number S 3786 26 Antibody Type Recombinant mAb Isotype IgG Application IHC P Reactivity Hu Purification Protein
Product Specification
| Host | Rabbit |
| Antigen | LYVE1 |
| Synonyms | Lymphatic vessel endothelial hyaluronic acid receptor 1; Cell surface retention sequence-binding protein 1 (CRSBP-1); Extracellular link domain-containing protein 1; Hyaluronic acid receptor; CRSBP1; HAR; XLKD1 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q9Y5Y7 |
| Clone Number | S-3786-26 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | Hu |
Background
Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) is a type I integral membrane glycoprotein belonging to the Link protein superfamily, primarily characterized by its high-affinity binding to hyaluronan (HA), a major component of the extracellular matrix. Predominantly expressed on the surface of lymphatic endothelial cells in both developing and adult tissues, LYVE-1 serves as a definitive marker for identifying lymphatic vessels, distinguishing them from blood vessels, although it is also transiently found on liver sinusoidal endothelial cells and certain macrophage populations during embryogenesis or inflammation. Structurally, it shares homology with CD44, another HA receptor, yet possesses unique functional properties that facilitate the uptake and transport of HA from peripheral tissues into the lymphatic system, thereby playing a critical role in maintaining tissue fluid homeostasis, regulating immune cell trafficking, and modulating inflammatory responses. Beyond its physiological functions in lymphangiogenesis and HA clearance, LYVE-1 has significant clinical relevance as its expression is often upregulated in tumor-associated lymphatics, making it a valuable target for studying cancer metastasis and a potential diagnostic marker for lymphatic malformations and various carcinomas.
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