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Description
Her3 His Tag Protein, MouseProduct Specification Species Mouse Synonyms Her3, ERBB3, LCCS2, MDA BF 1, MGC88033, c erbB3, erbB3 S, p180 ErbB3, p45 sErbB3, p85 sErbB3 Accession Q61526 Amino Acid Sequence Ser20 His641, with C terminal 10*His
Product Specification
| Species | Mouse |
| Synonyms | Her3, ERBB3, LCCS2, MDA-BF-1, MGC88033, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3 |
| Accession | Q61526 |
| Amino Acid Sequence | Ser20-His641, with C-terminal 10*His SEMGNSQAVCPGTLNGLSVTGDADNQYQTLYKLYEKCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRFTQLTEILLGGVYIEKNDKLCHMDTIDWRDIVRVPDAEIVVKNNGGNCPPCHEVCKGRCWGPGPEDCQILTKTICAPQCNGRCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPAPLVYNKLTFQLEPNPHIKYQYGGVCVASCPHNFVVDQTFCVRACPADKMEVDKNGLKMCEPCRGLCPKACEGTGSGSRYQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRVYISANQQLCYHHSLNWTRLLRGPAEERLDIKYNRPLGECVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSREGVCVTHCNVLQGEPREFVHEAHCFSCHPECQPMEGTSTCNGSGSDACARCAHFRDGPHCVNSCPHGILGAKGPIYKYPDAQNECRPCHENCTQGCKGPELQDCLGQAEVLMSKPHGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 80-95kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Zhang N. et al. (2016) HER3/ErbB3, an emerging cancer therapeutic target. Acta Biochim Biophys Sin. 48(1): 39-48. |
Background
HER3 is a member of the HER (EGFR/ErbB) receptor family consisting of four closely related type 1 transmembrane receptors (EGFR, HER2, HER3, and HER4). HER receptors are part of a complex signaling network intertwined with the Ras/Raf/MAPK, PI3K/AKT, JAK/STAT, and PKC signaling pathways. Aberrant activation of the HER receptors and downstream signaling molecules tips the balance on cellular events, leading to various types of cancers. The HER3 protein is expressed in several types of tumors. That fact, together with the role of HER3 in promoting cell proliferation, implicate that targeting HER3 may have therapeutic relevance. Furthermore, expression and activation of HER3 has been linked to resistance to drugs that target other HER receptors such as agents that act on EGFR or HER2.
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4.1 ★★★★★
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★★★★★ 3
The book itself is good. The content may be awkward or detailed in ...
Format: Paperback
The book itself is good. The content may be awkward or detailed in a way that makes reading tedious and a bit less enjoyable than what likw.
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Reviewed in the United States on April 28, 2016
★★★★★ 5
Nursing school book that helps
Format: Paperback
I use this book for nursing school :0.
The book covers a broad range of topics including cardiovascular diseases, respiratory conditions, diabetes, mental health, and much more. Each chapter is written by experts in the field, providing a high level of expertise and insight into best practices for managing various medical conditions.
One of the things I appreciate about this book is the clear and concise writing style. The guidelines are presented in a format that is easy to understand and follow, making it an ideal resource for busy practitioners. Additionally, the authors have included helpful algorithms and decision trees to aid in the management of complex cases.
Another strength of this book is the emphasis on evidence-based medicine. The guidelines are based on the latest research and are regularly updated to reflect new developments in the field. This ensures that healthcare professionals can provide the most effective and appropriate care for their patients.
Overall, I highly recommend Clinical Guidelines in Primary Care for healthcare professionals working in primary care settings. It is a comprehensive and practical guide that provides evidence-based recommendations for the diagnosis and management of a wide range of medical conditions.
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Reviewed in the United States on March 19, 2023
★★★★★ 5
Great Resource
Format: Paperback
As a resource for NP school (and even after, I'm sure), this book is fantastic. I recommend it to anyone asking if it's worth it. I, however, refer them to a different site than Amazon as it is cheaper straight from the publisher. Significantly so. A hundred dollars difference doesn't quite justify the next day or 2-day delivery.
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Reviewed in the United States on March 2, 2025
★★★★★ 5
So good for soap notes!
Format: Paperback
I wish I could have gotten this sooner when we had to write soap notes. It explains the illness, symptoms, tests, treatments, referrals and follow ups. I got it used and it came in great condition. Would definitely buy again!
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Reviewed in the United States on July 12, 2024
★★★★★ 5
Bible!
Format: Paperback
This book has been my life line with school. Freaking amazing and worth every penny.
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Reviewed in the United States on February 22, 2024