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Description
PBEF/Visfatin/NAMPT Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen PBEF Visfatin NAMPT Synonyms Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; Pre B cell colony enhancing factor 1 (Pre B cell enhancing factor); Visfatin; PBEF1 Immunogen Recombinant Protein Location Cytoplasm, Nucleus, Secreted Accession P43490 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample HeLa, HT 1080, K562, MCF7, PC 3 Purification Immunogen
Product Specification
| Host | Rabbit |
| Antigen | PBEF/Visfatin/NAMPT |
| Synonyms | Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; Pre-B-cell colony-enhancing factor 1 (Pre-B cell-enhancing factor); Visfatin; PBEF1 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus, Secreted |
| Accession | P43490 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | HeLa, HT-1080, K562, MCF7, PC-3 |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:500 | Hu |
| ICC | 1:500 | Hu |
Background
PBEF/Visfatin/NAMPT is a multifunctional 52-kDa protein that acts both intracellularly as the rate-limiting enzyme nicotinamide phosphoribosyltransferase (EC 2.4.2.12) in the NAD salvage pathway—catalyzing conversion of nicotinamide to nicotinamide mononucleotide (NMN)—and extracellularly as an adipokine/cytokine circulating in blood; it enhances B-lymphocyte precursor maturation, inhibits neutrophil apoptosis, binds and activates the insulin receptor to exert insulin-mimetic glucose-lowering effects, promotes vascular smooth-muscle cell maturation, modulates endothelial function, and its serum levels correlate with obesity and metabolic syndrome, while intracellularly it maintains the NAD⁺ pool essential for processes such as SIRT1 activity, DNA repair and β-cell glucose-stimulated insulin secretion.
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