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Description
Alexa Fluor® 488 Rabbit Anti-Human CD27 Antibody (S-1205-49)Product Specification Host Rabbit Antigen CD27 Synonyms CD27 antigen; CD27L receptor; T cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7Imported; TNFRSF7 Immunogen Recombinant Protein Location Cell membrane Accession P26842 Clone Number S 1205 49 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Hu Positive Sample Human peripheral blood lymphocytes Purification Protein A Concentration 0. 2 mg ml
Product Specification
| Host | Rabbit |
| Antigen | CD27 |
| Synonyms | CD27 antigen; CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7Imported; TNFRSF7 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P26842 |
| Clone Number | S-1205-49 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood lymphocytes |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD27 protein is a member of the tumor necrosis factor (TNF) receptor superfamily. It is expressed on the surface of various immune cells such as T cells and B cells. CD27 can interact with its ligand CD70, which is mainly found on antigen - presenting cells (APCs) and activated T cells. This interaction plays a crucial role in the regulation of immune responses. It can promote T cell proliferation and differentiation, enhance the cytotoxic activity of T cells against infected or cancerous cells, and also participate in the regulation of B cell functions such as immunoglobulin production. Moreover, the CD27 - CD70 pathway is involved in the development and maintenance of immune memory, helping the immune system to remember and respond more effectively to pathogens it has previously encountered. Abnormal expression or function of CD27 has been implicated in certain immune - related diseases and cancers, making it a potential target for therapeutic interventions in these conditions.
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Exchange/Return Notes
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