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Description
Alexa Fluor® 647 Rat Anti-Mouse CD226 Antibody (S-R625)Product Specification Host Rat Antigen Mouse CD226 Synonyms CD226 antigen; Platelet and T cell activation antigen 1; Pta1 Location Cell membrane Accession Q8K4F0 Clone Number S R625 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3% Proclin 300
Product Specification
| Host | Rat |
| Antigen | Mouse CD226 |
| Synonyms | CD226 antigen; Platelet and T-cell activation antigen 1; Pta1 |
| Location | Cell membrane |
| Accession | Q8K4F0 |
| Clone Number | S-R625 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD226 (also known as DNAM-1) is a member of the immunoglobulin superfamily and is expressed on the surface of T cells, natural killer (NK) cells, monocytes, and macrophages. It enhances the activation, proliferation, and cytotoxic functions of T cells and NK cells by binding to its ligands CD155 and CD112 and activating downstream signaling pathways such as PI3K-AKT and VAV-1-ERK. CD226 plays a crucial role in anti-tumor immunity, with its high expression associated with better responses to immune checkpoint blockade therapies. However, its function can be inhibited by TIGIT, which competes with CD226 for binding to CD155, thereby dampening immune activation. CD226 is also involved in regulating the function of regulatory T cells (Tregs), and its absence in Tregs can exacerbate inflammatory diseases. Thus, CD226 holds potential not only in cancer immunotherapy but also in the study of autoimmune diseases.
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