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Description
Jak1 Recombinant Rabbit mAb (S-4201)Product Specification Host Rabbit Antigen JAK1 Synonyms Tyrosine protein kinase JAK1; Janus kinase 1 (JAK 1); JAK1A; JAK1B; JAK1 Accession P23458 Clone Number S 4201 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HDLM 2, K562, PC 3, DU 145, CTLL 2, PC 12 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA,
Product Specification
| Host | Rabbit |
| Antigen | JAK1 |
| Synonyms | Tyrosine-protein kinase JAK1; Janus kinase 1 (JAK-1); JAK1A; JAK1B; JAK1 |
| Accession | P23458 |
| Clone Number | S-4201 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HDLM-2, K562, PC-3, DU 145, CTLL-2, PC-12 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:2000 | Hu, Ms, Rt |
Background
Jak1 (Janus kinase 1) is a 130-kDa, membrane-proximal tyrosine kinase that associates with the cytoplasmic tails of cytokine receptors—such as those for interferons, interleukins and gp130 family ligands—and, upon ligand-driven receptor clustering, trans-autophosphorylates its activation loop and then phosphorylates STAT proteins to trigger rapid gene-expression programs governing immunity, hematopoiesis and growth; because its ATP-binding cleft can be occupied by ruxolitinib, upadacitinib or other clinical inhibitors, Jak1 is a validated drug target in autoimmune diseases, myeloproliferative neoplasms and alloimmune disorders.
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Exchange/Return Notes
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