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Description
Invivo Anti-Human IL-12 p70 Recombinant mAbProduct Specification Host Rat Antigen IL 12 p70 Synonyms Interleukin 12 Location Secreted Accession P29459P29460 Clone Number S 3751 Antibody Type Rat mAb Isotype Rat IgG1,k Application ELISA, WB, Functional Assay Reactivity Hu Purification Protein G Concentration 5 mg ml Purity >95%(Determined by SDS PAGE) Endotoxin <1EU mg Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, containing no preservative Stability & Storage 2
Product Specification
| Host | Rat |
| Antigen | IL-12 p70 |
| Synonyms | Interleukin-12 |
| Location | Secreted |
| Accession | P29459、P29460 |
| Clone Number | S-3751 |
| Antibody Type | Rat mAb |
| Isotype | Rat IgG1,k |
| Application | ELISA, WB, Functional Assay |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95%(Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
Interleukin-12 p70 (IL-12 p70) is a disulfide-linked heterodimeric cytokine composed of a 35-kDa light chain (p35) and a 40-kDa heavy chain (p40), functioning as the biologically active form of IL-12 secreted primarily by antigen-presenting cells such as dendritic cells, macrophages, and B cells upon recognition of pathogens; it drives the differentiation of naïve CD4+ T cells toward the Th1 phenotype, synergizes with IL-18 to induce large amounts of IFN-γ from T and NK cells, bridges innate and adaptive immunity, and is implicated in protective immunity against intracellular bacteria, viruses, and tumors, yet its dysregulation contributes to autoimmune and inflammatory disorders.
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