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Description
Alexa Fluor® 700 Mouse Anti-Human CD11a Antibody (S-R402)Product Specification Host Mouse Antigen CD11a Synonyms Integrin alpha L; CD11 antigen like family member A; Leukocyte adhesion glycoprotein LFA 1 alpha chain (LFA 1A); Leukocyte function associated molecule 1 alpha chain; CD11A; ITGAL Location Cell membrane Accession P20701 Clone Number S R402 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation
Product Specification
| Host | Mouse |
| Antigen | CD11a |
| Synonyms | Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain (LFA-1A); Leukocyte function-associated molecule 1 alpha chain; CD11A; ITGAL |
| Location | Cell membrane |
| Accession | P20701 |
| Clone Number | S-R402 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 700 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD11a, also known as integrin alpha L, is a protein encoded by the ITGAL gene in humans and is a critical component of the leukocyte function-associated antigen-1 (LFA-1) complex, which is essential for immune cell adhesion and signaling. It pairs with CD18 to form LFA-1, a heterodimeric transmembrane protein that mediates interactions between leukocytes and other cells, such as T cells and antigen-presenting cells. This interaction is crucial for leukocyte migration to sites of inflammation and the formation of immunological synapses. CD11a is expressed on all leukocytes and plays a key role in immune surveillance and inflammatory responses. It is also a target for therapeutic agents like efalizumab, which was used to treat psoriasis by inhibiting the interaction between LFA-1 and its ligands, such as ICAM-1.
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