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Description
mTOR Recombinant Rabbit mAb (S-698-228)Product Specification Host Rabbit Antigen mTOR Synonyms Serine threonine protein kinase mTOR; FK506 binding protein 12 rapamycin complex associated protein 1; FKBP12 rapamycin complex associated protein; Mammalian target of rapamycin (mTOR); Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1; Tyrosine protein kinase mTOR; MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1 Immunogen Synthetic Peptide Accession P42345 Clone
Product Specification
| Host | Rabbit |
| Antigen | mTOR |
| Synonyms | Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin (mTOR); Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1; Tyrosine-protein kinase mTOR; MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1 |
| Immunogen | Synthetic Peptide |
| Accession | P42345 |
| Clone Number | S-698-228 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | K562, Raji, HeLa, HepG2, MCF7, C2C12, C6 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:250 | Hu |
| ICC | 1:500 | Hu |
Background
The mammalian target of rapamycin (mTOR) protein is a crucial serine/threonine kinase that plays a central role in regulating various cellular processes such as cell growth, proliferation, survival, and metabolism. It integrates signals from multiple pathways including nutrient availability, growth factors, and energy status to control protein synthesis, lipid metabolism, and autophagy. mTOR exists in two distinct complexes: mTORC1 and mTORC2. mTORC1, which is sensitive to rapamycin, is primarily involved in promoting protein synthesis by phosphorylating key substrates like S6K and 4E-BP1, thereby driving cell growth and division. It also inhibits autophagy when nutrients are abundant. mTORC2, on the other hand, regulates the actin cytoskeleton and cell survival by phosphorylating proteins such as Akt and PKC. Dysregulation of mTOR signaling is implicated in numerous diseases including cancer, diabetes, and neurodegenerative disorders, making it an important target for therapeutic interventions.
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