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Description
Thyroglobulin Recombinant Rabbit mAb (SDT-209-297)Product Specification Host Rabbit Antigen Thyroglobulin Synonyms Tg, TG Immunogen Native protein Location Secreted Accession P01266 Clone Number SDT 209 297 Antibody Type Rabbit mAb Application IHC P, IF Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 125 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as supplied
Product Specification
| Host | Rabbit |
| Antigen | Thyroglobulin |
| Synonyms | Tg, TG |
| Immunogen | Native protein |
| Location | Secreted |
| Accession | P01266 |
| Clone Number | SDT-209-297 |
| Antibody Type | Rabbit mAb |
| Application | IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.125 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | null |
| IF | 1:125 | null |
Background
Thyroglobulin is a large protein used by the thyroid gland to make thyroid hormones (T4 and T3) and store iodine in the body, made in the thyroid by the so-called follicular cells. When the thyroid is stimulated by thyroid-stimulating hormone (TSH), it combines iodine with thyroglobulin to create the hormones T4 and T3. While most thyroglobulin stays in the thyroid, a small amount leaks out into the bloodstream. Levels in the blood are directly proportional to the size of the thyroid. For example, thyroid cancer cells enlarge the gland and make thyroglobulin in high amounts. Any disorder that increases the size of the thyroid (cancer, autoimmune disease, nodules, etc.) can raise thyroglobulin levels.
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