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Description
LAG3 Recombinant Rabbit mAb (SDT-R159)Product Specification Host Rabbit Antigen LAG3 Synonyms Lymphocyte activation gene 3 protein Immunogen N A Location Cell membrane Accession P18627 Clone Number SDT R159 Antibody Type Recombinant mAb Application IHC P, IF Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as
Product Specification
| Host | Rabbit |
| Antigen | LAG3 |
| Synonyms | Lymphocyte activation gene 3 protein |
| Immunogen | N/A |
| Location | Cell membrane |
| Accession | P18627 |
| Clone Number | SDT-R159 |
| Antibody Type | Recombinant mAb |
| Application | IHC-P, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | |
| IF | 1:500 |
Background
LAG3 (CD223) is the third IR to be targeted in the clinic. It is a potential cancer immunotherapeutic target due to its negative regulatory role on T cells and its capacity, in combination with PD1, to mediate a state of exhaustion [PMID: 26018646]. LAG3 up-regulation is required to control overt activation and prevent the onset of autoimmunity. However, persistent antigen exposure in the tumor microenvironment results in sustained LAG3 expression, contributing to a state of exhaustion manifest in impaired proliferation and cytokine production. The exact signaling mechanisms downstream of LAG3 and interplay with other IRs remains largely unknown. However, the striking synergy between LAG3 and PD1 observed in multiple settings, coupled with the contrasting intracellular cytoplasmic domain of LAG3 as compared with other IRs, highlights the potential uniqueness of LAG3. There are now four LAG3-targeted therapies in the clinic with many more in preclinical development [PMID: 28258692].
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4.1 ★★★★★
Based on 17 reviews
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Product Reviews
★★★★★ 5
These are definitely indestructible
Size: Medium
Both of my dogs can destroy a ball in a matter of minutes if I let them play with them (supervised) as is. Well not with these balls. They are the ONLY ones I have found that are 100% indestructible. Please only let your dogs play with these as a toy when supervised though. They go really far when throwing them, so both dogs get a good amount of running and exercise with these. I also bought these because they have the hole in the middle of the ball which is very important in the event that a dog gets one stuck at the back of their throat. This allows them to breath unlike those without this hold. It's an unlikely event, but as dog owners, we all need to be aware of this and educate ourselves on what to do if this SHOULD happen. This isn't a scare tactic, nor a reflection of this particular brand, it can happen with any type of ball. My two dogs are about 45ish lbs and the size is perfect for them, I don't want anything smaller than this. They love them. There is no annoying squeak. Really easy to wash after use. Some balls take forever to get the slimy saliva off, but these don't.
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Reviewed in the United States on September 25, 2025
★★★★★ 5
He loves this ball
Size: Medium, Size: Medium
My dog loves this ball. It’s the perfect size, he enjoys playing fetch and this ball has been his fav one. Thank you guys for making my lil one happy
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Reviewed in the United States on May 2, 2026
★★★★★ 5
Best toy, the end
Style: Sport, Size: 12in, Style: Sport, Size: 12in
Combined with the Max Glow ball, this is the best dog toy available on modern planet Earth.
I have a burly 92lb. pit bull mix with highly developed prey drive, and she will chase the glow ball for hours if I let her.
The tiny sport launcher (Sport 12M) is the best, because you can still throw the ball really far, but you can also slam the ball down a few feet away from yourself so it bounces up in the air and your dog has to jump to catch it, or you can throw it up really high so it bounces 15' away or so and your dog can jump to catch it. We sometimes have to play fetch in a pretty small area, so it's nice to have the small launcher for these games. The larger launchers aren't as fun in small areas. You can play the same games but it's trickier to throw the ball correctly.
Also, the small launcher is a lot easier to carry. The small launcher fits in my dog-walk-stuff backpack (with the ball in the launcher so I don't have to dig for it later), but the big ones don't easily. The launcher also has a hole in the end so you can hang it from your bag or whatever with a carabiner. The big ones are too long for that in most cases, and swing back and forth.
Also-also my dog loves to ask for the launcher, then when I give it to her she plays keep-away and it's adorable. The big launcher I have is harder for her to balance in her mouth, so she just lays down and chews on it until it gets taken away. She's chewed on all of the four Chuck Its we've owned, but she's only broken one (a big one), but that's because she got ahold of it when no one was home. The little one in my bag is totally chewed up but still works great. I think they're sturdier than the big ones. Except for the launcher she chewed into pieces, which was our fault, the only reason we've had to replace anything was because we lost it. Usually we keep the launcher and ball in the backpack so she can't get to them and so they don't get lost, so we rarely have to replace them. There is just not a better value in toys, and the startup price is really low.
Once again I really recommend the glow ball! It doesn't get soggy no matter how wet the grass or the dog mouth is. It is fun to chase because it is slippery and it collapses when it's squeezed, so it pops out of the dog's mouth and flies away if they bite it at the wrong angle; it's really bouncy, and stays bouncy because it can't be popped; it whistles so you can usually hear it even if you can't see it; and it really glows enough for nighttime catch, even if you only have your cellphone flashlight to charge it up!
UPDATE:
I should have said, we have the 12M launcher, which means the handle is 12 inches long and it uses a medium-sized ball. The medium ball is 2.5 inches in diameter, so the launcher will fit regular tennis balls, too! But my dog won't play with regular tennis balls anymore because they aren't anywhere near as fun as the glow balls, and I think she doesn't like having gross sloshy muddy tennis balls in her mouth.
I lost my short launcher awhile back and could only get a long one locally to replace it, which reminded me that you have to lean over a lot further to use the short launcher. So if you have trouble leaning over to the point that your hand is a foot above the ground, this may be hard for you to use.
I wish Amazon would let us choose colors, because my old one was green, and the big one is orange, both of which are bright enough to see in the grass from far away, even at night.
Still, best toy!
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Reviewed in the United States on May 19, 2017
★★★★★ 5
Highly recommend.
Style: Sport, Size: 12in
Love this. Dog sitting for a dog that loves to chase balls but my shoulder doesn’t like throwing them. Got this yesterday and it’s perfect. Real arm/shoulder saver.
Seems sturdy and I was concerned that a standard tennis ball would not work. We tend to lose balls when walking because this lab insists on carrying the ball in its mouth. They work.
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Reviewed in the United States on March 22, 2026
★★★★★ 5
These are awesome and I couldn't play ball with my Dobermans without it!
Style: Sport, Size: 12in
I LOVE Chuckit ball launchers. We've been using for a around 17 years and we've only had to replace one. We have 2 active, energetic Dobermans and I throw like a girl and there is now way I can throw a ball very far. With the Chuckit, I can throw more than 80 feet! My dogs need a lot of exercise and using this ball thrower allows me to make that happen. Bonus is I dont have to pick up a snobbery ball :)
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Reviewed in the United States on April 13, 2026