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Description
IL-27 Protein, HumanProduct Specification Species Human Synonyms IL 27 p28 subunit,IL 27 subunit alpha,IL27,IL 27,IL27A,IL 27 A,IL27 A,IL27p28,IL30,interleukin 27,interleukin 30,interleukin 27 subunit alpha,MGC71873,p28IL 27A Amino Acid Sequence Arg21 Lys229 (Q14213) Phe29 Pro243 (Q8NEV9) Expression System HEK293 Molecular Weight 27 33 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized
Product Specification
| Species | Human |
| Synonyms | IL-27 p28 subunit,IL-27 subunit alpha,IL27,IL-27,IL27A,IL-27-A,IL27-A,IL27p28,IL30,interleukin 27,interleukin 30,interleukin-27 subunit alpha,MGC71873,p28IL-27A |
| Amino Acid Sequence | Arg21-Lys229 (Q14213) |
| Expression System | HEK293 |
| Molecular Weight | 27-33 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH 7.4, 5%Trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Annu Rev Immunol. 2015:33:417-43. |
Background
Interleukin-27 (IL-27) is a heterodimeric cytokine that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of two subunits: EBI3 (EBV-induced gene 3), which is related to the p40 subunit of IL-12 and IL-23, and p28, which is related to the p35 chain of IL-12. IL-27 is primarily produced by monocytes, endothelial cells, and dendritic cells. It signals through a heterodimeric receptor complex composed of WSX-1 (TCCR) and gp130. IL-27 has both anti-inflammatory and pro-inflammatory properties. As an anti-inflammatory cytokine, it induces a general negative feedback program that limits T and NK-T cell activity. During the onset of infection, IL-27 induces an IL-12 receptor on naïve CD4+ T cells, making them susceptible to subsequent IL-12 activity and possible Th1 development.
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