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Description
Cyclin A2 Recombinant Rabbit mAb (S-1873-103)Product Specification Host Rabbit Antigen Cyclin A2 Synonyms Cyclin A2; Cyclin A; Cyclin A; CCN1; CCNA; CCNA2 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P20248 Clone Number S 1873 103 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa, Jurkat, HEK 293, NIH 3T3, RAW264. 7, mouse spleen, PC 12, C6, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | Cyclin A2 |
| Synonyms | Cyclin-A2; Cyclin-A; Cyclin A; CCN1; CCNA; CCNA2 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P20248 |
| Clone Number | S-1873-103 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, Jurkat, HEK-293, NIH/3T3, RAW264.7, mouse spleen, PC-12, C6, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:200 | Hu, Ms |
| ICC | 1:500 | Hu |
Background
Cyclin A2 is a pivotal regulatory protein that orchestrates S-phase progression and the G2/M transition by binding and activating cyclin-dependent kinases Cdk2 and Cdk1, thereby phosphorylating substrates that initiate DNA replication origin firing, centrosome maturation, and chromosomal condensation; its expression rises during late G1, peaks in S and G2, and is abruptly degraded via APC/C-mediated ubiquitination in prometaphase to prevent premature mitotic exit, and deregulation—through gene amplification, transcriptional upregulation, or impaired destruction—drives genomic instability and oncogenesis, making it both a biomarker and therapeutic target in multiple cancers.
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