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Description
TAOK1 Recombinant Rabbit mAb (S-3673-80)Product Specification Host Rabbit Antigen TAOK1 Synonyms Serine threonine protein kinase TAO1; Kinase from chicken homolog B (hKFC B); MARK Kinase (MARKK); Prostate derived sterile 20 like kinase 2 (PSK 2; PSK2; Prostate derived STE20 like kinase 2); Thousand and one amino acid protein kinase 1 (TAOK1; hTAOK1); KIAA1361; MAP3K16; MARKK Immunogen Synthetic Peptide Location Cytoplasm Accession Q7L7X3 Clone Number S 3673 80 Antibody Type Recombinant mAb
Product Specification
| Host | Rabbit |
| Antigen | TAOK1 |
| Synonyms | Serine/threonine-protein kinase TAO1; Kinase from chicken homolog B (hKFC-B); MARK Kinase (MARKK); Prostate-derived sterile 20-like kinase 2 (PSK-2; PSK2; Prostate-derived STE20-like kinase 2); Thousand and one amino acid protein kinase 1 (TAOK1; hTAOK1); KIAA1361; MAP3K16; MARKK |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | Q7L7X3 |
| Clone Number | S-3673-80 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, Jurkat, A549, RAW264.7, NIH/3T3, mouse brain, mouse heart, C6, rat brain, rat heart |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
TAOK1 (TAO kinase 1) is a multifunctional serine/threonine protein kinase and a member of the MAP3K family. It activates the p38/MAPK14 stress signaling pathway through phosphorylation of MAP2K3/MAP2K6, regulates microtubule dynamic stability by phosphorylating MARK2 (its ability to phosphorylate TAU protein is associated with tauopathies), and participates in DNA damage checkpoints as well as the JNK apoptotic cascade. In the nervous system, TAOK1 induces neurite initiation via phosphorylation of MARK2 and downstream TAU; its autophosphorylation at Thr440 or phosphorylation by MST3 kinase enables interaction with myosin Va to promote dendritic spine and synaptic maturation. Mutations in the TAOK1 gene have been confirmed to be closely associated with autosomal dominant neurodevelopmental disorders, including developmental delay, autism spectrum disorder, and intellectual disability. Furthermore, in cardiomyocytes, this kinase alleviates heart failure-related damage by inhibiting NLRP3 inflammasome activation and restoring YAP/TEAD pathway activity.
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