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Description
Tau (phospho T231) Recombinant Rabbit mAb (SDT-177-1)Product Specification Host Rabbit Antigen Tau (phospho T231) Synonyms p Tau231, phospho T231, Phospho Tau (Thr231) Immunogen Synthetic Peptide Location Cytoplasm, Secreted, Cell membrane Accession P10636 8 Clone Number SDT 177 1 Antibody Type Rabbit mAb Application WB, IP Reactivity Ms Predicted Reactivity Cz, Gor, Pr, Or, Hu, Mq Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0.
Product Specification
| Host | Rabbit |
| Antigen | Tau (phospho T231) |
| Synonyms | p-Tau231, phospho T231, Phospho-Tau (Thr231) |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Secreted, Cell membrane |
| Accession | P10636-8 |
| Clone Number | SDT-177-1 |
| Antibody Type | Rabbit mAb |
| Application | WB, IP |
| Reactivity | Ms |
| Predicted Reactivity | Cz, Gor, Pr, Or, Hu, Mq |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IP | 1:50 |
Background
The functions of the neuronal microtubule-associated protein Tau in the central nervous system are regulated by manifold posttranslational modifications at more than 50 sites. Tau in healthy neurons carries multiple phosphate groups, mostly in its microtubule assembly domain. Elevated phosphorylation and aggregation of Tau are widely considered pathological hallmarks in Alzheimer's disease (AD) and other tauopathies, triggering the quest for Tau posttranslational modifications in the disease context [PMID: 33892381]. Tau phosphorylation at Thr231 can be detected in cerebrospinal fluid and shows potential as a biomarker of neurofibrillary pathology in Alzheimer’s disease [PMID: 17012293].
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4.1 ★★★★★
Based on 6 reviews
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Product Reviews
★★★★★ 5
IT'S LIKE SLEEPING ON A CLOUD!!
Size: King, Style: 3 White
OMG I AM SLEEPING ON A CLOUD!!! THIS! Life changing!!! We went on a Royal cruise and asked for a mattress topper. When we got home I just had to find one for our bed because I sometimes find it to be too hard. Along comes THIS topper! The very first night it was on the bed I slept the entire night without tossing / turning which I NEVER do! Along with every night since! It fits perfectly on our King bed and no issues with the sheets. It does have a chemical smell when you first open the bag - but I put it in the dryer on air only and the smell dissipated in about 20 minutes. No smell at all by the time we went to bed. it appears to be washable. It's very soft so there isn't really any back support. Just adds comfort to the bed. It is bamboo and really as soft as a cloud! Even my husband got into bed the first night and said AHHHHHHH SOFFT! Super bright white appearance. Not sure if it is water resistant. We added it on top of the mattress protector without any issues. All of the FOAM mattress toppers are terrible! They end up getting really heavy, you can't wash them, they get lumpy, and you end up sweating like crazy on them! THIS - nice and cool! And my hubby runs hot!! I call him the heat miser! No issues! We're both very very pleased!! If you're even thinking about purchasing - ADD IT TO YOUR CART NOW!
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Reviewed in the United States on April 22, 2026
★★★★★ 4
Not like the pictures but well worth the money
Size: Queen, Style: 1 Green
4 stars because it is not nearly as padded as the descriptions and images make it seem. The filling flattens easily and doesn’t provide any support.
That being said it does make my bed more comfortable and soft and has improved my sleep quality. I have a 12 in soft/medium firm memory foam mattress that was wonderful for the last +2 years till my back surgery ~6 months ago. Since then my joints ached when trying to sleep and when waking, my back would be all out of place and achey, and I was untested. Since buying this topper these issues have improved by 80% or more. It is a great addition to my bed and I don’t regret buying it.
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Reviewed in the United States on May 18, 2026
★★★★★ 5
OMGAAAAAWD!!! HEAVEN!
Size: Full, Style: 1 Green, Size: Full, Style: 1 Green
All I can say is OMGAWD!!! Thank You~!~!! We got a new mattress after the previous "The Cloud" Serta pillow top (I'll never have another one) lasted for less than 8 years and I totally despised not being able to flip it models failed.. The new model is also a hybrid mattress, but is flippable and was just a bit too firm. I was feeling progressively more and more uncomfortable as the nights wore on, and with my serious back problems.. this just wouldn't do.. So I began searching "Our Beloved Amazon - heh" for an alternative, and after quite some time and research finally landed on this wonderful topper. It's like sleeping on top of well stuffed Ida Down on top of piles of silk. So very comfortable and my back pain is virtually completely gone now -such a relief! Be sure you follow the instructions on care and initial setup. You Do have to let it fluff out because of the vacuum packing (it wasn't really heavy btw). Mine decompacted fine, but I still want to run it through the dryer when we next venture to the laundromat. Shake it a little here and there when you take it out and at least let it sit for a few hours. It was just as easy to put on the bed as a regular mattress protector, and I also put my regular protector on top of it for added security and waterproofing. The materials feel like they are of good quality.. Viscose is also called Rayon and can be made from a number of different materials, so take good care of it and follow the washing instructions carefully. Delicate only, and cool only, and use only a horizontal washer that does not have a central agitator or you will tear it up. Only dry on low temperatures (preferably in a very larger laundromat dryer so it has plenty of room to loosely toss about. Drying it in the sun is alright as well, but it won't fluff like you want it to. I recommend using a waterproof and bug proof protector on top of this just to be sure you take care of it properly.
Now I want to buy one for both my Mother and my Aunt HAHAHHA! TG it is in my price range.. barely.
(Addendum: I have run it through the big dryer at the laundromat.. The dryer was cold so I gave it a quick warm on medium for anout 2 minutes and then tumbled on low for quite some time. The topper was fully ready in about 25 minutes, but I decided to elt it go on low while I did the rest of my laundry. It did perfectly and is just like the manufacturer photos.. I was so tired when I arrived home that I just flaked out on top of everything.. It was so comfortable that I was out liek a light in very short order and slept beautifully. I can attest that if you use this below your sheets instead of covering it with an additional mattress protector, that it does have better cooling effect. I will of course keep my waterproof/bugproof protector on top just for safety. The cat is nutz about the new topper as well.)
Namaste.
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Reviewed in the United States on August 6, 2025
★★★★★ 5
Pleasantly surprised!
Size: Queen, Style: 2 Dark Gray
I had been searching for a quality mattress topper in hopes of extending the life of our mattress. I compared a few options and kept coming back to this one. I have to admit I was skeptical because the price point was lower than many options. This topper is SO comfortable and soft! I left it laying out for a couple hours and then followed the instructions to put it in the dryer. Worked like a charm. I’ve been going through issues with hip pain and this has made a difference in my sleep and I’m waking up in less pain. So happy I tried this out. The padding is so comfortable and fit on the mattress using the same sheet we had.
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Reviewed in the United States on May 17, 2026
★★★★★ 5
So perfectly soft
Size: King, Style: 2 Dark Gray
My husband was complaining about the mattress, and wants to spend a lot of money on a new one like the ones at the Waldorf. I asked him to give me a chance to try to fix it first. Watched youtube videos about hotel style beds, and landed on the need for a mattress topper.
This one is so... very... comfortable. I thought the grid pattern would bother me, but nope. You don't realize how much heat you soak up from your mattress until you get a nice airy layer in between. I almost completely stopped sweating at night, and he's stopped complaining about hurting as much.
This is another of those items that I'm scared of washing too much, but it's held up with care and caution. If it starts to get a bit too squished, I just fluff it in the dryer and the padding poofs right back up. The sides are deep and my mattress sinks right into the pocket with no pulling. I have bad back pain and I am certain this has been helping support my back a bit better, so I wake up more refreshed. I'm sorta popping out of bed like I used to years ago.
He still plans on a new mattress, but this has saved us money, for now, and when we get the new one, this will layer on top like a dream. I'm glad I took the chance on this, it has really improved our rest, and that's so important.
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Reviewed in the United States on May 16, 2026
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