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Description
p14ARF Recombinant Rabbit mAb (S-R244)Product Specification Host Rabbit Antigen p14ARF Synonyms Tumor suppressor ARF, Alternative reading frame (ARF), Cyclin dependent kinase inhibitor 2A, CDKN2A, MLM Location Nucleus Accession Q8N726 Clone Number S R244 Antibody Type Recombinant mAb Application WB, IHC P, ICC, ICFCM, IP Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03%
Product Specification
| Host | Rabbit |
| Antigen | p14ARF |
| Synonyms | Tumor suppressor ARF, Alternative reading frame (ARF), Cyclin-dependent kinase inhibitor 2A, CDKN2A, MLM |
| Location | Nucleus |
| Accession | Q8N726 |
| Clone Number | S-R244 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, ICFCM, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC | 1:100 | null |
| ICFCM | 1:500 | null |
| ICC | 1:500 | null |
| IP | 1:50 | null |
Background
p14ARF (also called ARF tumor suppressor, ARF, p14ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus). p14ARF is induced in response to elevated mitogenic stimulation, such as aberrant growth signaling from MYC and Ras (protein). It accumulates mainly in the nucleolus where it forms stable complexes with NPM or Mdm2. These interactions allow p14ARF to act as a tumor suppressor by inhibiting ribosome biogenesis or initiating p53-dependent cell cycle arrest and apoptosis, respectively.
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