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Description
IRF3 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen IRF3 Synonyms IRF3; Interferon regulatory factor 3; IRF 3 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Mitochondrion Accession Q14653 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Positive Sample HeLa, NIH3T3 Conjugation Unconjugated Physical Appearance Liquid Storage Buffer 50mM Tris Glycine (pH 7. 4), 0. 15M NaCl, 40%Glycerol, 0. 01% sodium
Product Specification
| Host | Rabbit |
| Antigen | IRF3 |
| Synonyms | IRF3; Interferon regulatory factor 3; IRF-3 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Mitochondrion |
| Accession | Q14653 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, NIH3T3 |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | |
| IHC-P | 1:50-1:100 | |
| ICC | 1:50-1:200 | |
| ICFCM | 1:50-1:100 |
Background
IRF3 (Interferon Regulatory Factor 3) is a crucial transcription factor in the IRF family, playing a central role in innate immunity, particularly in antiviral responses. Upon viral invasion, pattern recognition receptors (e.g., TLR3, RIG-I) recognize viral components and, through adaptor proteins (TRIF, MAVS), activate the kinases TBK1/IKKε, leading to phosphorylation of the C-terminal domain of IRF3. This results in the formation of IRF3 homodimers, which translocate to the nucleus. In the nucleus, IRF3 cooperates with transcription factors such as NF-κB to activate the expression of type I interferons (IFN-α/β) and pro-inflammatory cytokines, initiating a broad-spectrum antiviral state. Additionally, IRF3 can induce apoptosis in infected cells to limit viral spread. Its activity is regulated by viral evasion mechanisms (e.g., HCV cleavage of MAVS), and its dysregulation is associated with autoimmune diseases and cancer pathology.
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