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Description
FITC Rat Anti-Mouse F4/80 Antibody (S-R537)Product Specification Host Rat Antigen F4 80 Synonyms Adhesion G protein coupled receptor E1; Cell surface glycoprotein F4 80; EGF like module receptor 1; EGF like module containing mucin like hormone receptor like 1; EMR1 hormone receptor; Emr1; Gpf480; Adgre1 Location Cell membrane Accession Q61549 Clone Number S R537 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample mouse peritoneal exudates cells Purification
Product Specification
| Host | Rat |
| Antigen | F4/80 |
| Synonyms | Adhesion G protein-coupled receptor E1; Cell surface glycoprotein F4/80; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; Emr1; Gpf480; Adgre1 |
| Location | Cell membrane |
| Accession | Q61549 |
| Clone Number | S-R537 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | mouse peritoneal exudates cells |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| 5μl per million cells in 100μl volume | Ms |
Background
F4/80, also known as EGF-like module-containing mucin-like hormone receptor-like 1 (EMR1), is a cell surface glycoprotein that is a member of the EGF-TM7 protein family. It is primarily used as a marker for mature macrophages in mice and shows significant expression changes during the maturation and activation of these cells. F4/80 is expressed on various mature macrophage populations, including Kupffer cells, Langerhans cells, microglia, and macrophages located in the peritoneum, intestinal lamina propria, splenic red pulp, lung, thymus, and bone marrow stroma. This antigen is encoded by the Adgre1 gene, which is a seven transmembrane G protein-coupled receptor with an extracellular domain containing repeated Epidermal Growth Factor (EGF)-like calcium binding domains. The F4/80 antigen is not only crucial for the phenotypic characterization of macrophages but also plays a role in immune regulation, as indicated by studies showing its necessity for inducing CD8+ regulatory T cells responsible for peripheral immune tolerance.
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