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Description
GDF-5/BMP-14 Protein, HumanProduct Specification Species Human Synonyms BMP14, CDMP1, LAP 4, LPS associated protein 4 Accession P43026 Amino Acid Sequence Ala382 Arg501 Expression System E. coli Molecular Weight 28kDa (Non reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 50mM HAc, pH2. 9 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Synonyms | BMP14, CDMP1, LAP-4, LPS-associated protein 4 |
| Accession | P43026 |
| Amino Acid Sequence | Ala382-Arg501 |
| Expression System | E.coli |
| Molecular Weight | 28kDa (Non-reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 50mM HAc, pH2.9 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Jin L, Li X. Growth differentiation factor 5 regulation in bone regeneration. Curr Pharm Des. 2013;19(19):3364-73. |
Background
Human growth differentiation factor 5 (GDF5) is one of the bone morphogenetic proteins (BMPs) belonging to the transforming growth factor β (TGF-β) superfamily. It has commercial value as a therapeutic protein because of its ability to induce cartilage and bone formation, and angiogenesis in adult animals. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations of GDF5 are associated with several human and animal diseases that are characterized by skeletal deformity such as short digits and short limbs.
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