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Description
PINP Recombinant Rabbit mAb (SDT-237-59)Product Specification Host Rabbit Antigen PINP Synonyms N terminal propeptide of type 1 precollagen Immunogen Recombinant Protein Accession P02452 Clone Number SDT 237 59 Antibody Type Rabbit mAb Application Sandwich ELISA Reactivity Hu Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Physical Appearance Liquid Storage Buffer PBS, pH 7. 4, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as
Product Specification
| Host | Rabbit |
| Antigen | PINP |
| Synonyms | N-terminal propeptide of type 1 precollagen |
| Immunogen | Recombinant Protein |
| Accession | P02452 |
| Clone Number | SDT-237-59 |
| Antibody Type | Rabbit mAb |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH 7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| Sandwich ELISA | N/A | null |
Background
N-terminal propeptide of type 1 precollagen (P1NP) is one of the markers of bone formation. Osteoblasts contain a large amount of typeⅠprecollagen. During bone formation, typeⅠprocollagen is secreted outside the cell and cleaved by specific protease to form typeⅠcollagen N-terminal procollagen of type 1 precollagen (P1NP) and C-terminal procollagen of type 1 precollagen, PICP) and typeⅠcollagen 3 fragments. Type I collagen is assembled in osteoid where inorganic minerals (calcium and phosphorus) are deposited to form hydroxyapatite (osteoid mineralization). P1NP and PICP enter the blood and urine as metabolites, so the detection of P1NP and PICP can reflect the level of bone formation. As the research evidence of P1NP reflecting bone formation is richer than PICP, P1NP is a better marker of bone formation. P1NP has good specificity, little influence on circadian rhythm and feeding, and is stable at room temperature. At present, P1NP is generally recommended as the preferred bone formation marker.
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