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Description
Human IgG1 Fc , His tagProduct Specification Species Human Synonyms Immunoglobulin heavy constant gamma 1, Ig gamma 1 chain C region, Ig gamma 1 chain C region EU, Ig gamma 1 chain C region KOL, Ig gamma 1 chain C region NIE, IGHG1 Accession P01857 Amino Acid Sequence Protein sequence(P01857, Asp104 Lys330(D239E,L241E), with C 10*His)
Product Specification
| Species | Human |
| Synonyms | Immunoglobulin heavy constant gamma 1, Ig gamma-1 chain C region, Ig gamma-1 chain C region EU, Ig gamma-1 chain C region KOL, Ig gamma-1 chain C region NIE, IGHG1 |
| Accession | P01857 |
| Amino Acid Sequence | Protein sequence(P01857, Asp104-Lys330(D239E,L241E), with C-10*His) DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEETKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:27.2kDa Actual:30kDa |
| Purity | ＞90% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This property allows antibodies to activate the immune system. Fc binds to various cell receptors and complement proteins. In this way, it mediates different physiological effects of antibodies (detection of opsonized particles; cell lysis; degranulation of mast cells, basophils, and eosinophils; and other processes).
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4.1 ★★★★★
Based on 25 reviews
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Product Reviews
★★★★★ 1
Wrangler's failure or yours...
Fit Type: Very Tight, Color: Overdyed Black, Size: 64W x 34L
I bought a pair earlier and they were too small despite every detail being correct by comparison of every other label I have ever had on. I thought maybe they are just made a little small, fine. I bought this pair 2 sizes bigger. The are not only also too small, but they are the identical size as the one before it. Its like they just took the same pair and attached a different label to clear out that inventory. I'm not saying they did, but when i compare the two pair, they are exactly the same size!!!
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Reviewed in the United States on April 30, 2019
★★★★★ 2
Least comfortable cut of pants I own.
Fit Type: Very Tight, Color: Black, Size: 48W x 32L
I'm usually not picky when it comes to jeans, but the fit and cut on these is downright uncomfortable. Right size, but just terrible to wear. Least favorite jeans I own.
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Reviewed in the United States on February 18, 2022
★★★★★ 5
wrangler pants
Great deal on a great pair of pants. Brand new and fairly priced. It would have cost more, in a store. No complaints at all. 2 thumbs up.
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Reviewed in the United States on April 23, 2014
★★★★★ 5
Got what I wanted without issues
Received as expected - no issues at this point. I will use them again if service continues at the current displayed level
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Reviewed in the United States on March 25, 2023
★★★★★ 5
great pants
Fit Type: Very Tight, Color: Black, Size: 48W x 32L
Super durable ... perfect fit ... thank you!
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Reviewed in the United States on December 29, 2023