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Description
Mitofilin Recombinant Rabbit mAb (S-2277-37)Product Specification Host Rabbit Antigen Mitofilin Synonyms MICOS complex subunit MIC60; Cell proliferation inducing gene 4 52 protein; Mitochondrial inner membrane protein; p87 89; HMP; MIC60; MINOS2; IMMT Immunogen Synthetic Peptide Location Mitochondrion Accession Q16891 Clone Number S 2277 37 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms, Rt Positive Sample HeLa, HepG2, Saos 2, mouse testis, rat testis
Product Specification
| Host | Rabbit |
| Antigen | Mitofilin |
| Synonyms | MICOS complex subunit MIC60; Cell proliferation-inducing gene 4/52 protein; Mitochondrial inner membrane protein; p87/89; HMP; MIC60; MINOS2; IMMT |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | Q16891 |
| Clone Number | S-2277-37 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, HepG2, Saos-2, mouse testis, rat testis |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| IF | 1:100 | Ms, Rt |
Background
Mitofilin protein is an integral component of the mitochondrial inner membrane, playing a crucial role in maintaining mitochondrial structure and function. It is a highly conserved protein across various species and is involved in stabilizing the inner membrane architecture, particularly in the formation and maintenance of cristae, which are the invaginations of the inner membrane that increase the surface area for energy production through oxidative phosphorylation. Additionally, Mitofilin has been implicated in processes such as mitochondrial dynamics, including fusion and fission events, and it may also contribute to the regulation of mitochondrial respiration and overall cellular energy metabolism.
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