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Description
CGRP Recombinant Rabbit mAb (S-2490-74)Product Specification Host Rabbit Antigen CGRP Synonyms Calcitonin gene related peptide 1; CGRP1; Alpha type CGRP; Calcitonin gene related peptide I (CGRP I); CALC1; CALCA Immunogen Synthetic Peptide Location Secreted Accession P06881 Clone Number S 2490 74 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample TT Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | CGRP |
| Synonyms | Calcitonin gene-related peptide 1; CGRP1; Alpha-type CGRP; Calcitonin gene-related peptide I (CGRP-I); CALC1; CALCA |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | P06881 |
| Clone Number | S-2490-74 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | TT |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:10000 | Hu |
| IHC-P | 1:500 | Hu, Ms, Rt |
Background
CGRP (calcitonin gene-related peptide) is a 37-amino-acid neuropeptide produced by tissue-specific splicing of the CALCA gene in primary afferent sensory neurons and central neurons; it signals through a heterodimeric receptor composed of the G-protein-coupled receptor CALCRL and the accessory protein RAMP1, potently dilating cerebral and dermal vasculature, modulating nociceptive transmission, and mediating neuro-inflammatory responses, making it a key target for monoclonal antibodies and small-molecule antagonists in the prevention of migraine and the treatment of cluster headache.
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Exchange/Return Notes
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