SKU: 21184259108

KCNQ2 Recombinant Rabbit mAb (S-3465-49)

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Description

KCNQ2 Recombinant Rabbit mAb (S-3465-49)Product Specification Host Rabbit Antigen KCNQ2 Synonyms Potassium voltage gated channel subfamily KQT member 2; KQT like 2; Neuroblastoma specific potassium channel subunit alpha KvLQT2; Voltage gated potassium channel subunit Kv7. 2 Immunogen Synthetic Peptide Location Cell membrane Accession O43526 Clone Number S 3465 49 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample mouse brain, rat brain

Product Specification


Host Rabbit
Antigen KCNQ2
Synonyms Potassium voltage-gated channel subfamily KQT member 2; KQT-like 2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Voltage-gated potassium channel subunit Kv7.2
Immunogen Synthetic Peptide
Location Cell membrane
Accession O43526
Clone Number S-3465-49
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms, Rt
Positive Sample mouse brain, rat brain
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt

Background

The KCNQ2 protein is a voltage-gated potassium channel α-subunit, encoded by the KCNQ2 gene, that plays a critical role in regulating neuronal excitability throughout the central nervous system. Predominantly expressed in the brain, KCNQ2 primarily forms heterotetrameric complexes with KCNQ3 subunits to constitute the M-current (IKM), a slowly activating, non-inactivating potassium current that acts as a crucial brake on repetitive neuronal firing by stabilizing the resting membrane potential and preventing excessive depolarization. Functionally, this current is activated at subthreshold membrane potentials and is essential for controlling action potential threshold, firing frequency, and burst accommodation in neurons. Clinically, mutations in KCNQ2 are associated with a spectrum of epileptic disorders, ranging from benign familial neonatal epilepsy (BFNE) to severe developmental and epileptic encephalopathies (DEE) characterized by refractory seizures, intellectual disability, and neurodevelopmental impairment. The KCNQ2 channel serves as the primary pharmacological target for retigabine (ezogabine), an antiepileptic drug that activates the channel by inducing a conformational shift favoring the open state, thereby enhancing the M-current and reducing neuronal hyperexcitability. Structurally, KCNQ2 contains six transmembrane domains (S1-S6), with the S4 segment functioning as the voltage sensor and the S5-S6 loop forming the channel pore, while intracellular domains mediate subunit assembly, trafficking, and calmodulin-dependent regulation of channel gating kinetics.

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SKU: 21184259108

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joymom
Birmingham, US
★★★★★ 5
Great Value for a ball my dog loves!
Color: S6-muti-color
I wish these ball were in the subscription program! My dog gets sooo excited by the new ball, but her interest in things lasts for a few days. She kills the squeak within 11minutes, but the squeaker stays in place rather than becoming a chocking or swallow hazard, and she still loves to chew it. Next, we must throw the ball approximately 723 times the first day, possibly 496 times on day 2, and just 3- 4 on day 3, at which point she will chase the ball before hollering "it's over here if you need it," while she checks on the chipmunk den. We currently have 17 of these balls in our yard (because we have given several leftovers to a less discriminating doodle next door). These balls hold up really well, get her extremely active for the first couple of days, and are a much cheaper than doggie daycare (after an active morning with a new ball, she is happy to chew on it and sleep much of the day). I always have these on hand!
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Reviewed in the United States on November 22, 2025
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Michelle
Lexington, US
★★★★★ 4
Pieces chewed off
Color: white & green
My Aussiedoodle loves it. I throw it down the hallway, it bounces crazy, and he chases it. The only complaint is that he can't chew much of the ball part. So now I have to have it put away and brought out for special playtime.
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Reviewed in the United States on April 9, 2026
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Ramey Fair
Carnegie, US
★★★★★ 5
Great toys
My 3-year-old Maltese destroys stuffed toys in short order. These toys with no stuffing keep her busy for hours without the risk of ingesting a bunch of loose stuffing. She loves them and carries them around the house making them squeak. Very durable for a toy destroyer like my little girl.
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Reviewed in the United States on April 3, 2026
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jhDub
Houston, US
★★★★★ 5
Fantastic toys! Your pup will love them!
My dogs love beating the ever loving **** out of these trusty squeaky toys. They’re durable, they last a long time, and they give my dogs plenty of entertainment. There’s no stuffing, which means zero cleanup. And the fact that you get 5 toys is a great value! They’re also super cute. I actually feel bad watching my dogs chew them.
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Reviewed in the United States on April 28, 2025
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PeachyPicks
Grantham, US
★★★★★ 5
Dog loves these!
My dog absolutely loves these toys! They hold up pretty well, the squeakers dont last long, but I am actually glad for that because I can only take so much squeaking. He gets so excited when I take a new one out and he carries them around everywhere. These are his favorite toys, by far.
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Reviewed in the United States on May 9, 2026

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