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Description
CFTR Recombinant Rabbit mAb (SDT-2133-154)Product Specification Host Rabbit Antigen CFTR Synonyms Cystic fibrosis transmembrane conductance regulator; ATP binding cassette sub family C member 7; Channel conductance controlling ATPase; cAMP dependent chloride channel; ABCC7 Immunogen Synthetic Peptide Location Cell membrane, Endoplasmic reticulum membrane Accession P13569 Clone Number SDT 2133 154 Antibody Type Recombinant mAb Isotype IgG Application IHC P, IF Reactivity Hu Positive Sample
Product Specification
| Host | Rabbit |
| Antigen | CFTR |
| Synonyms | Cystic fibrosis transmembrane conductance regulator; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; cAMP-dependent chloride channel; ABCC7 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Endoplasmic reticulum membrane |
| Accession | P13569 |
| Clone Number | SDT-2133-154 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, IF |
| Reactivity | Hu |
| Positive Sample | Human pancreas |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:250 | Hu |
| IF | 1:100 | Hu |
Background
The CFTR protein, or cystic fibrosis transmembrane conductance regulator protein, is a crucial membrane protein found primarily in epithelial cells lining various organs such as the lungs, pancreas, and sweat glands. It functions as a chloride channel, regulating the movement of chloride ions across cell membranes to maintain proper fluid balance and mucus consistency. Mutations in the CFTR gene can lead to cystic fibrosis, a genetic disorder characterized by thick, sticky mucus buildup in the lungs and digestive system, causing chronic infections and impaired organ function. The CFTR protein also plays a role in regulating sodium channels and has broader implications for epithelial cell function and ion transport.
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