Pay in installments of $181.25 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 31 - Aug 5
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
human pgp vesicle kit hek293P Glykoproteine MDR1 Assay 100 Reaktionen Das Human Pgp Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient P Glykoprotein (P gp MDR1 ABCB1) berexprimieren. P gp ist einer der klinisch relevantesten Efflux Transporter und ist an zentralen pharmakokinetischen Barrieren wie Darm, Leber, Niere und Blut Hirn Schranke exprimiert. Das Kit ist konform mit den FDA (2017) und EMA (2013) DDI Leitlinien. Hergestellt von Cell4Pharma.
P-Glykoproteine / MDR1 Assay | 100 Reaktionen
Das Human Pgp Vesicle Kit enthält Inside-out-Membranvesikel aus HEK293-Zellen, die transient P-Glykoprotein (P-gp / MDR1 / ABCB1) überexprimieren. P-gp ist einer der klinisch relevantesten Efflux-Transporter und ist an zentralen pharmakokinetischen Barrieren wie Darm, Leber, Niere und Blut-Hirn-Schranke exprimiert. Das Kit ist konform mit den FDA (2017)- und EMA (2013)-DDI-Leitlinien.
Hergestellt von Cell4Pharma. Eine Variante mit dem neuartigen fluoreszenten FluoPgp-Substrat ist ebenfalls erhältlich (C4PVK011).
Exklusiv im DACH-Raum über SeamlessBio erhältlich.
Transporter-Profil
Name: P-gp, P-Glykoprotein, MDR1, Multidrug Resistance Protein 1, Permeabilitätsglykoprotein, ABCB1, ATP-bindende Kassette Unterfamilie B Mitglied 1
Gen: ABCB1
ATP/AMP-Ratio: >5 (garantiert)
Gewebsexpression: Darm, Leber, Niere, Blut-Hirn-Schranke, viele Tumorzellen
Bekannte Substrate: Convallatoxin, Digoxin, N-Methyl-Chinidin (NMQ), Colchicin, Tacrolimus, Chinidin, Etoposid, Doxorubicin
Lagerbestand: Human-Pgp. Ebenfalls verfügbar: Maus- und Ratten-Pgp
Kit Inhalt (100 Reaktionen)
-
- AMP-ATP Lösung (100 mM), Cell4Pharma
- Assay-Puffer, Cell4Pharma
Hinweis: C4PVK011 enthält zusätzlich das neuartige FluoPgp Fluoreszenzsubstrat für fluoreszenzbasierte Detektion ohne Radiolabeling.
Anwendungen
- P-gp-Substratidentifikation und Efflux-Charakterisierung
- Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien
- Studien zur Multiresistenz (MDR)-Mechanistik
- In-vitro-Bewertung der Blut-Hirn-Schranken-Penetration
- Inhibitionsstudien und IC50-Bestimmung
- High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)
Regulatorische Konformität
P-Glykoprotein (ABCB1) ist ein primärer Transporter in den FDA (2017)- und EMA (2013)-DDI-Leitlinien. Die Bewertung des P gp-Substrat-und Inhibitorstatus ist für alle neuen Molekülentitäten (NMEs) mit signifikanter oraler oder systemischer Exposition in der klinischen Entwicklung erforderlich.
Technische Spezifikationen
Wirtszelle: HEK293 (humane embryonale Nierenzelle) Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel Variante mit FluoPgp-Substrat: C4PVK011
Lagerung: –80 °C
Verwandte Produkte
- Human Pgp Vesicle Kit + FluoPgp Substrat (C4PVK011)
- Fluoreszenz-Detektionsvariante, kein Radiolabeling erforderlich
- Human BCRP Vesicle Kit (C4PVK006) – für parallele BCRP-Efflux-Bewertung
- Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle
- ciPTEC-OAT1 Assay-Ready Cells – exprimieren funktionelles endogenes P-gp (ABCB1) für zellbasierte Bestätigungsstudien
- Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
Kontakt: [email protected] | Telefon: +49 851 37932226
Datasheet
Publikation
Gozalpour E, Wittgen HG, van den Heuvel JJ, et al. Interaction of digitalis-like compounds with p-glycoprotein. Toxicol Sci. 2013,131(2):502-11. doi: 10.1093/toxsci/kfs307
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.8 ★★★★★
Based on 24 reviews
Sort
Product Reviews
★★★★★ 5
Cozy Omegaverse
Format: Kindle
This is the true definition of Cozy Omegaverse. LA wedding coordinator meets her pack at the location for a couple’s destination wedding. Low angst because they are scent matched high heat with heats and knots. Everything you love about this genre with very little anxiety. Simply a fun experience to read and a book I will comeback to when I’m in a slump. I simply love reading this book
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 19, 2026
★★★★★ 4
Cute Omegaverse story
Format: Kindle
3.75 stars and 2 for spice. Adorable Omegaverse story about a wedding planner who has to go to a small town to plan a wedding for a movie star. While there, she meets her pack. This covers her struggles of not living there but trying to keep her relationship going with her 3 Alphas.
It's a quick read and cute, so I recommend it for people who like light-hearted RH stories.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 31, 2025
★★★★★ 3
real good
Format: Kindle
This was a solid read for the ABO universe. The characters are great. The smut scenes were well written. And the town is so cute I want to go there. It didn’t have much character development it just felt like I was getting to the characters as they were getting to know each other.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 27, 2025
★★★★★ 5
So sweet
Format: Kindle
It’s so unexpectedly sweet that it sneaks up on you. Each character is so unique and charming. I love the openness and honesty among their pack. It really blows me away how wonderful this omegaverse trope plays out.
I received a free copy of this book and am voluntarily leaving a review.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 21, 2026
★★★★★ 2
Needs editing
Format: Kindle
Cute storyline and promising characters, but the lack of editing is painful to read. I would love to read an edited version.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 10, 2025