Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 10 - Jul 15
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Pacific Blue Mouse Anti-Human CD61 Antibody (S-R618)Product Specification Host Mouse Antigen CD61 Synonyms Integrin beta 3; Platelet membrane glycoprotein IIIa (GPIIIa); GP3A; ITGB3 Location Cell membrane, Synapse Accession P05106 Clone Number S R618 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human peripheral blood platelets Purification Protein G Concentration 0. 2 mg ml Conjugation Pacific Blue Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3%
Product Specification
| Host | Mouse |
| Antigen | CD61 |
| Synonyms | Integrin beta-3; Platelet membrane glycoprotein IIIa (GPIIIa); GP3A; ITGB3 |
| Location | Cell membrane, Synapse |
| Accession | P05106 |
| Clone Number | S-R618 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood platelets |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Pacific Blue |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD61, also known as integrin beta-3 (ITGB3) or glycoprotein IIIa (gpIIIa), is a transmembrane protein encoded by the ITGB3 gene in humans. It is predominantly expressed on the surface of platelets and megakaryocytes. CD61 forms a crucial complex with CD41 (alphaIIb) to create the heterodimeric receptor gpIIb/IIIa, which is essential for platelet aggregation and thrombus formation. This receptor binds to fibrinogen, von Willebrand factor, and other extracellular matrix proteins, facilitating platelet adhesion and aggregation. In addition to its role in hemostasis, CD61 is also involved in various cellular processes, including cell adhesion, migration, and proliferation. It has been implicated in tumor progression, where it can influence tumor metabolism, immune microenvironment, and epithelial-to-mesenchymal transition.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy