SKU: 87097093269

Hista Clear - DAO Enzyme (60 tablets)

Sale price$57.60 Regular price$64.00
Save 10%

Pay in installments of $16.00 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 25 - Aug 30

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

Hista Clear - DAO Enzyme (60 tablets)NEW: Now in NEW packaging Conners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) the main enzyme responsible for the degradation of ingested histamine. This enzyme has been clinically tested and found to break down food derived histamine in the digestive tract. Our bodies are complex, and there is usually more at play than we think. What most dont take into consideration when addressing histamine related

NEW: Now in NEW packaging

Conners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) - the main enzyme responsible for the degradation of ingested histamine.  This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract.  

Our bodies are complex, and there is usually more at play than we think. What most don’t take into consideration when addressing histamine-related health issues is genetics. Whether you’re on a low histamine diet due to histamine intolerance, or simply trying to reduce high histamine foods for general health, you will benefit from understanding how your genes are related. Learn more about histamine and genetics here!

Our body has two distinct methods of clearing things that could bring it harm: our immune system kills living toxins (bacteria, virus, parasites…) and our detoxification pathways clear non-living toxins (chemicals, heavy metals, drugs…). We have one other system that sits somewhere in the middle between the immune and the detoxification systems that helps with both: the mast cells. Read more about Histamine’s Double-edge Sword in the Formation and Progression of Cancer.

 

Clinical Applications
  • Supports Healthy Degradation of Food-Derived Histamine*
  • Enhances the Presence of Diamine Oxidase in the Digestive Tract*
Description:


Hista Clear provides a concentrated source of diamine oxidase (DAO)—the main enzyme responsible for the degradation of ingested histamine. This formula delivers the clinically researched dose of DAO in an easy-to-swallow, gastro-resistant mini-tablet, which is essential for releasing DAO in the small intestine, where it breaks down food-derived histamine. HistDAO does not manage or address antibody-related or IgE-related food allergies.*

Discussion:

Histamine is a bioactive or “vasoactive” amine produced in the body in response to an injury or foreign substance. It has an array of physiological effects, including increasing blood supply to specific sites in the body. In addition, histamine is involved in the immune response, regulation of gastric acid, permeability of blood vessels, contraction of muscles, and the normal response to inflammation.[1] The highest concentrations of histamine in the body are found in the gastrointestinal tract, lungs, and skin, with lesser amounts in the brain and heart.*

Histamine is not only produced in the body but is also present in many fermented foods, such as sauerkraut, sausage, cheese, yogurt, and alcoholic beverages. Tuna, olives, spinach, eggplant, avocados, tomatoes, cherries, and citrus fruits are other histamine-containing foods. Despite their absence of histamine, some foods, such as berries, tea, and a variety of spices, stimulate the endogenous production of the amine due to their benzoate content. In addition, microbial fermentation can convert the histidine in high-protein foods to histamine so that the histamine content of food can increase over time.*[1]

Endogenous and exogenous histamine must be broken down in order to maintain homeostasis and histamine balance. The enzyme diamine oxidase (DAO) degrades histamine by converting it from 2-(4-imidazolyl)- ethylamine to the inactive metabolite imidazole acetaldehyde.[2] The active ingredient in HistaClear is porcine-derived diamine oxidase, and research suggests that DAO derived from porcine kidney appears to have identical action to DAO derived from porcine intestine.[3] In humans and other mammals, DAO is found in high concentrations in the gastrointestinal mucosa. Animal studies suggest that circulating DAO may be a marker for mucosal integrity and maturity.[4] Certain drugs may affect histamine balance in the body by promoting histamine release or inhibiting DAO.*[2]

Histamine tolerance may not be the same for everyone. Results of a double-blind, placebo-controlled crossover study suggest that tolerance to histamine can vary from individual to individual.[5] Total body histamine load must be considered when evaluating histamine tolerance, and a balance between histamine and DAO appears to be crucial to maintaining skin, rhinoconjunctival, and gastrointestinal health.[2,6] Genetic and environmental factors may interact to influence DAO expression. Ongoing research addresses the role that genetic variations may play in individual differences in DAO metabolism, and serum activity was significantly associated with seven single nucleotide variations within the DAO gene.[7,8] Histamine tolerance may be reflected in detailed questionnaires, food intake logs, trial with low-histamine diet, and measurement of DAO and histamine.*[9,10]

Histamine tolerance and its manifestation may vary from organ to organ as well. A study of 39 patients suggested that intake of DAO produced a statistically significant reduction in symptoms associated with exogenous histamine ingestion, although single symptoms were not found to be reproducible.*[11]

Ultimately, diminished serum DAO levels appear to be associated with changes in histamine degradation and serum histamine levels.[10] Although the mechanism of histamine degradation is uniform throughout the body, HistaClear only addresses excess exogenous histamine found in the folds, villi, and microvilli of the small intestine. HistaClear is not absorbed and therefore does not have systemic activity. A two-capsule dose of HistaClear contains 20 mg of vitamin C and 20,000 HDU (histamine degrading units) from diamine oxidase. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.*

Read our article: Low Histamine Diet: The High Histamine Foods List

Genetic supplementation is complex and requires a deep understanding of the entire genetic picture.  Our Genetics Membership includes the kit, a full workup, review, report, summary, Dr. Conners’ personalized recommendations - and MORE.  Click HERE for details.

Video:


Directions:

Take 1-2 capsules no more than 15 minutes before the consumption of histamine-rich foods, or take as directed by your healthcare practitioner.

Cautions:

Consult your healthcare practitioner before use, especially if you are pregnant or nursing. Keep out of reach of children. Avoid if allergic to pork or any other ingredient. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.


Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 87097093269

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.8 ★★★★★
Based on 18 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
B
Verified Purchase
Brooklynn Porter
Grantham, US
★★★★★ 5
Fantastic quality
Style: Wi-Fi, Size: 128GB, Color: Pink, Configuration: Without AppleCare+
iPad works great. I had some issues with the delivery, but once I received the package everything was fine. I use it every day and it’s super easy to use, battery life is really good and it does everything I need it to
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 18, 2026
H
Verified Purchase
Harold Ball
Lexington, US
★★★★★ 5
To use or not to use
Style: Wi-Fi, Size: 128GB, Color: Silver, Configuration: Without AppleCare+
Very easy to set up Looked brand new Works like new Well worth the money The battery lasts all damn day
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 16, 2026
M
Verified Purchase
Mads
Omaha, US
★★★★★ 4
Its Great! Except one tiny detail
Style: Wi-Fi, Size: 512GB, Color: Pink, Configuration: Without AppleCare+, Style: Wi-Fi, Size: 512GB, Color: Pink, Configuration: Without AppleCare+
Ipad works great, easy to set up and everything transferred from the cloud from a backup I had (thank god because my other ipad is completely dead). Everything is in order except they put the magnets in the wrong spot xD. It doesnt matter functionality wise and I feel its more hassle to exchange than its worth so I am going to keep the iPad. With the case its in it doesnt really matter because theres a spot already for the pen. 4/5 stars
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 13, 2026
M
Verified Purchase
MarshmelloFoxyYT
Lowell, US
★★★★★ 5
My iPad A16 Experience
Style: Wi-Fi, Size: 256GB, Color: Blue, Configuration: Without AppleCare+
The Gameplay Handles Very Well As It's Condition Is Really Good, The Screen Protection Is Very Durable On Hard Objects Tho Especially W Scratches Which Is Surprisingly different And Ofc The Battery Life It Does Last All Day So They Are Very Reliable On Their Answer, Very Good iPad.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 11, 2026
E
Verified Purchase
Eve G.
Lexington, US
★★★★★ 5
I like the style, fit, and quality of these tank shirts.
Color: Hot Pink, Size: Large
I absolutely love these tanks!!! They are very light and comfortable to wear anytime/ anywhere. I have bought lots of colors to mix and match my wardrobe. I'm 5'4" tall and weigh around 135 lbs. I normally wear a medium, but I am a busty girl, so I chose the large size instead. I'm happy with my choice. I wouldn't size up, if you are planning to buy, unless you have a bigger bust like myself. Then I would recommend sizing up. It can be worn either by itself or with a light jacket, vest, or cardigan sweater with a skirt/ slacks/ jeans/ whatever you fancy. This style tank can be worn for a casual occasion, lounging around your home, or can be paired for a fancier event depending on what you wear it with. Love that! I wash mine in cold, with like colors. Then hang dry so my tanks will last. These tanks have held their color nicely after several washes later. As long as I take care of them, I know they'll last. I prefer this seller when I buy various color tanks and styles because the fit and quality are a great value to me. These tanks don't feel cheap, ultra- thin, and are not see through like others. Go for it if your on the fence to try it! I don't think you'll regret it!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 1, 2026

recommand products