SKU: 84542922427

Sirtuin 6 Activator - 60 capsules

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Description

Sirtuin 6 Activator - 60 capsulesSirtuin 6 Activator: Inspired by the Blue Zones Activates sirtuin 6 (SIRT6)1,4,6,7* Provides Blue Zone bioactives*5,6 Supports multiple longevity pathways*5 Neutralizes free radicals*5,12 Supports a healthy immune system & inflammatory response* 8,5,9 11 View Certificate of Analysis Not all fucoidan is created equal. After three years of extensive research and testing, we've finally sourced an authentic Fucus vesiculosusa special type of seaweed

Sirtuin 6 Activator: Inspired by the Blue Zones

  • Activates sirtuin 6 (SIRT6)1,4,6,7*
  • Provides “Blue Zone” bioactives*5,6
  • Supports multiple longevity pathways*5
  • Neutralizes free radicals*5,12
  • Supports a healthy immune system & inflammatory response* 8,5,9-11

View Certificate of Analysis

Not all fucoidan is created equal. After three years of extensive research and testing, we've finally sourced an authentic Fucus vesiculosus—a special type of seaweed renowned for its powerful fucoidan content and abundant marine polyphenols. This premium seaweed extract sets a new benchmark in longevity science.* 2,5,8,13,21,22,25

What Makes Ours Better?

  • Fucoidan-Rich Seaweed: We deliver pure, concentrated seaweed—not synthetic compounds or low-quality extracts—packed with fucoidan, a potent SIRT6 activator.*21,22
  • Longevity Boost: Each serving provides a full 400mg dose of fucoidan, the scientifically-backed compound for healthy aging.*
  • Full Spectrum Support: Our formula blends whole-plant seaweed powder with high-potency extracts, offering a more complete range of bioactive compounds to amplify fucoidan’s anti-aging potential.*12,15
  • Maximized Bioactivity: Unlike many seaweed extracts that lose potency through harsh processing, our fucoidan is gently extracted using a specialized water-based method, preserving its full molecular structure for optimal effectiveness.*5

Why Choose ProHealth?

  • Doctor-Formulated: Developed by our in-house science team in collaboration with leading wellness experts to address the root causes of aging.*
  • Triple Lab Tested: Subjected to three rounds of independent third-party lab testing to ensure unmatched potency and purity.
  • Full Transparency: In an industry full of misleading claims, we publish our third-party lab results—so you always know exactly what’s in every bottle.
  • Manufactured in the USA: Made in FDA-regulated, GMP-certified facilities, adhering to the highest quality and safety standards.
  • 100-Day Risk-Free Guarantee: We’re confident you’ll love our product. If you’re not satisfied, contact our Santa Barbara, CA office for a full refund within 100 days—no hassle, no questions asked.

Not all fucoidan is created equal.

For centuries, Japan—home to one of the world’s longest-living populations—has relied on seaweed as a dietary staple, prized for its powerful antioxidants and cellular-protective compounds. Research consistently links regular seaweed consumption to enhanced health and longevity, reinforcing its vital role in healthy aging.*15

Building on this tradition, Sirtuin 6 Activator delivers fucoidan, one of seaweed’s most potent bioactive compounds. Naturally found in the cell walls of brown seaweed, fucoidan is clinically recognized for its ability to activate SIRT6, a key enzyme that supports healthy aging at the cellular level.*1


By activating SIRT6, this fucoidan-rich formula goes beyond simple antioxidant support to revitalize cellular health at its core. Research shows that increased SIRT6 activity can aid in DNA repair, boost genomic stability, and support a healthy systemic inflammatory response—processes linked to longevity in Blue Zone populations.*5,8,9,12,14,16

Emerging studies further suggest that higher SIRT6 activity correlates with longer lifespans in multiple animal species. Scientists are now exploring its potential for brain aging, heart health, and overall longevity, with human trials underway to further uncover its impact on healthy aging.*20,26-28


Sirtuin 6 Activator: Inspired by the Blue Zones

Aging is associated with cellular changes, including DNA damage, inflammation, and metabolic shifts, all of which have been studied in relation to SIRT6’s biological functions. Research suggests that SIRT6 plays a role in key cellular processes that support overall health.*

  • Supports DNA Repair – SIRT6 stabilizes the genome by repairing double-strand breaks and maintaining telomere integrity, reducing genetic instability, a major hallmark of aging.*6
  • Influences Metabolic Balance – SIRT6 shifts cells away from inefficient sugar metabolism and toward fat oxidation, mimicking the anti-aging effects of caloric restriction.*17
  • Clears Senescent Cells – Fucoidan acts as a potential senolytic, helping the body remove dysfunctional cells that drive aging.*4,13,19
  • Protects Mitochondria – SIRT6 supports healthy cellular energy production, safeguarding from oxidative stress so cells can generate energy efficiently.*5

Neutralizes Free Radicals*

Oxidative stress occurs when free radicals accumulate and damage cells, proteins, and DNA—a primary driver of aging. ProHealth Sirtuin 6 Activator combats oxidative damage through multiple pathways:

  • Directly Scavenges Free Radicals – Fucoidan’s unique sulfated polysaccharide structure binds to and neutralizes reactive oxygen species (ROS) before they can harm cells.*12
  • Provides Antioxidant Support – This formula combines fucoidan with polyphloroglucinols, marine polyphenols that strengthen cellular defenses against oxidative damage.*5
  • Enhances Cellular Antioxidant Pathways – By enhancing glutathione and superoxide dismutase (SOD) levels, SIRT6 supports the body’s natural ability to maintain oxidative homeostasis.*12

Supports a Healthy Immune System & Inflammatory Response*

Healthy immune system and inflammatory responses are essential for long-term health and longevity. Research suggests that fucoidan and SIRT6 may help support immune function and inflammation balance through multiple pathways:

  • Supports Immune Cell Activity – Fucoidan supports the activity of macrophages, natural killer (NK) cells, and lymphocytes, helping to maintain a robust immune system and clear damaged cells.*5,8,10
  • Helps Maintain a Healthy Inflammatory Response – SIRT6 influences cytokine activity and inflammatory response mechanisms, helping to support healthy inflammation for optimal aging.* 5,8,9
  • Enhances Gut-Immune Function – Fucoidan supports a healthy gut microbiome, which is closely linked to immune and inflammatory balance.*11

Order now and join the 200,000+ people who trust ProHealth Sirtuin 6 Activator for their cellular health!

Ingredients:

  • Brown Seaweed (Fucus vesiculosus): A rich source of fucoidan, a bioactive polysaccharide recognized for supporting cellular health and activating SIRT6, the longevity enzyme.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References:

  1. Rahnasto-Rilla M et al. Mar Drugs. 2017;15(6):190.
  2. Kawaguchi T et al. Int J Oncol. 2015;46(5):2216-2222.
  3. Yu W et al. Mol Nutr Food Res. 2017;61(10):1700136.
  4. Cao L et al. Mar Drugs. 2020;18(11):564.
  5. Li B et al. Molecules. 2008;13(8):1671-1695.
  6. López-Otín C et al. Cell. 2023;186(2):243-278.
  7. Iso H and Kubota Y. Asian Pac J Cancer Prev. 2007;8 Suppl:35-80.
  8. Jayawardena TU et al. Mar Drugs. 2022;20(12):755.
  9. Apostolova E et al. Polymers. 2020;12(10):2338.
  10. Bogolitsyn K et al. Plant Foods Hum Nutr. 2024;79(2):511-517.
  11. Luthuli S et al. Mar Drugs. 2019;17(9):487.
  12. Catarino MD et al. Mar Drugs. 2018;16(8):249.
  13. Zhang L et al. Innov Aging. 2022;6(Suppl 1):130.
  14. Myers S et al. Biol Targets Ther. 2011;45.
  15. Myers S. Biol Targets Ther. 2010;33.
  16. Li X et al. Front Cell Dev Biol. 2021;9:641315.
  17. Zhang N et al. Cell Cycle. 2016;15(7):1009-1018.
  18. Chilton WL et al. PLoS ONE. 2014;9(4):e92088.
  19. Akter R et al. Int J Mol Sci. 2021;22(8):4180.
  20. Zhang L et al. Innov Aging. 2022;6(Suppl 1):130.
  21. Gorbunova V. Innov Aging. 2019;3(Suppl 1):S8.
  22. Kawamura A et al. Mar Drugs. 2021;19(8):452.
  23. Willcox DC et al. Ann NY Acad Sci. 2009;1173:126-138.
  24. Buettner D. Natl Geogr Books. 2015.
  25. Korotkov A et al. Trends Cell Biol. 2021;31(12):994-1006.
  26. Zhang L et al. Oxid Med Cell Longev. 2019;2019:8918914.
  27. Yang J et al. Int J Biol Macromol. 2024;277(Pt 3):134397.
  28. Wang K et al. Ther Adv Chronic Dis. 2022;13:20406223221076891.
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving %DV
Fucoidan (from Bladderwrack [Fucus vesiculosus] Whole Plant Extract and Brown Seaweed [Undaria pinnatifida] Whole Plant Extract) 400 mg
Bladderwrack (Fucus vesiculosus) Whole Plant Powder 100 mg
† Daily Value (DV) not established
REV.10.24

  • OTHER INGREDIENTS: Vegetable cellulose (capsule), microcrystalline cellulose, bamboo silica.
    • May contain traces of fish and/or shellfish residue.
  • SUGGESTED DAILY USE: Take one (1) capsule daily, or as directed by your healthcare professional.
  • CAUTION: For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place after opening.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 84542922427

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Amazon Customer
Draper, US
★★★★★ 4
Fun while they lasted
Color: Green
I ordered two. One for each pup. Both my puppies loved this toy. The first one lasted less than a day with my pup who loves to do the death shake on everything. The second lasted two days with the other as she chews in the same spot. They loved the crinkle noise. However, I'm taking one star away due to not lasting long. Everything else was fine and they enjoyed them while they lasted. Note that most toys do not last long with my pups.
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Reviewed in the United States on May 4, 2026
A
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Alissa
Waukegan, US
★★★★★ 5
Puppy Loves this toy
Color: Tie Dye Blue
My puppy is a 7wk old Great Pyrenees & Lab mix. He loves this toy! Fun for tug of war and for cuddles. Definitely worth the money. It is durable enough for razor puppy teeth.
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Reviewed in the United States on June 9, 2026
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Marybeth Kenny
Birmingham, US
★★★★★ 5
Looks Even Better in Person!
Color: Rose Red
Does exactly what it says. Simple, effective, and high quality.
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Reviewed in the United States on May 19, 2026
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G
Belleville, US
★★★★★ 5
The pooch is on Cloud No 9
Color: Blue
Lucky loves everything about this (blue) octopus. It has squeakers in all the right places and the crinkle sound adds to his fun. He’s almost 70lbs and extremely strong, and can be an aggressive player and chewer. So far, it has held up extremely well for the tug-of-war games and crazy shaking play. It’s well worth the money. I also want to mention that this toy is true to size. I have too often ordered dog toys that turned out to be much smaller than advertised.
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Reviewed in the United States on January 15, 2026
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Amazon Customer
New York, US
★★★★★ 5
Great buy, finally a big soft toy, and so cute
Color: Green
This octopus toy is so adorable, I’m truly so impressed with the size finally a big toy for a big dog. She loves it! It squeaks, soft, made great. Worth it! Love it! Fun, durable n chewability just for play materials soft n durable. It’s a sea foam green color and creme beautiful neutral color
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Reviewed in the United States on January 31, 2026

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