SKU: 7421463777

Sirtuin 1 Activator - 60 capsules

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Description

Sirtuin 1 Activator - 60 capsulesSwitch On the Longevity Gene Activates and supports SIRT1*1 7 Promotes healthy aging at the cellular level*2,3,8 11 Strengthens the bodys antioxidant network*12 Helps maintain metabolic and inflammatory health*13 Boosts mitochondrial biogenesis and energy output*1,3 View Certificate of Analysis The Science of SIRT1 Inside every cell is a guardian protein called sirtuin 1 (SIRT1), short for Silent Information Regulator. It helps decide which parts of

Switch On the Longevity Gene

  • Activates and supports SIRT1*1-7
  • Promotes healthy aging at the cellular level*2,3,8-11
  • Strengthens the body’s antioxidant network*12
  • Helps maintain metabolic and inflammatory health*13
  • Boosts mitochondrial biogenesis and energy output*1,3

View Certificate of Analysis

The Science of SIRT1

Inside every cell is a guardian protein called sirtuin 1 (SIRT1), short for Silent Information Regulator. It helps decide which parts of your DNA stay quiet and which stay active, helping cells adapt to stress, maintain energy efficiency, and resist the effects of aging.

Commonly known as the "longevity switch," SIRT1 is involved in DNA repair, the removal of damaged cellular components, and the optimization of energy use. As we age, SIRT1 activity naturally declines due to factors such as oxidative stress, poor diet, disrupted sleep, and environmental challenges. This reduction is linked to diminished cellular resilience and many of the classic signs of aging.

The good news is that certain food compounds can help support SIRT1 function. Plant-derived polyphenols such as resveratrol (from red grapes) and pterostilbene (from blueberries) are among the best-studied for their ability to activate SIRT1 and promote healthy cellular aging. These compounds mimic calorie restriction at the molecular level, helping to reactivate SIRT1 and restore youthful gene expression patterns. By boosting SIRT1 activity, they help shift cells into a protective, repair-focused state, supporting the body’s natural defenses as we age.*1-7

Why Resveratrol + Pterostilbene Work Better Together

Resveratrol is well-known for supporting SIRT1, but the body clears it fast. The liver converts most of it into inactive metabolites within minutes. Blood levels fall quickly, so only a limited amount reaches cells. The effect on SIRT1 is meaningful, yet short-lived.*1-3,5-7

Pterostilbene shifts the profile. It is a close relative of resveratrol with two methyl groups that improve its performance.

  • Up to 4× higher oral bioavailability*
  • Greater lipophilicity for superior cellular penetration*
  • Significantly longer half-life in the body (up to 7× longer than resveratrol)*4,14-16

When used together in a balanced ratio, the two ingredients work in sequence. Resveratrol supports a fast SIRT1 response. Pterostilbene keeps that response active for a longer period due to its greater stability. This provides steadier sirtuin pathway support than resveratrol alone.*1-7,14-16

What Makes Ours Better?

  • 4:1 Polyphenol Complex: Balanced to reflect bioavailability differences between resveratrol and pterostilbene.
  • Clinically Studied Forms: Includes the active trans form of resveratrol and pterostilbene for consistency and purity.
  • Longevity Pathway Support: Engages SIRT1, AMPK and PGC-1α pathways linked to mitochondrial function and cellular upkeep.*1-7
  • Minimalist Formula: Uses only active polyphenols for a straightforward, clean profile.*

The ProHealth Difference

  • Doctor-Formulated: Developed by our in-house science team in collaboration with leading wellness experts.
  • Triple Lab Tested: Verified three times by independent labs for purity and potency.
  • Full Transparency: Third-party test results published online for complete confidence.
  • USA Manufactured: Proudly manufactured in the USA in FDA-registered, GMP-certified facilities since 1988.
  • 100-Day Risk-Free Guarantee: If you’re not fully satisfied, we’ll refund your purchase in full.

A Word from our Chief Science Officer

"Resveratrol brought SIRT1 into the spotlight, but bioavailability has always limited its potential. By combining it with pterostilbene, we’re matching kinetics with biology — ensuring both rapid activation and sustained support of this key longevity pathway."

Ingredient Info

Trans-Resveratrol: The active, naturally occurring form of resveratrol that supports key cellular pathways involved in healthy aging.*
Trans-Pterostilbene: A lipophilic stilbene that engages the SIRT1 pathway and complements resveratrol for steady cellular support.*

References:

  1. Della Vedova L et al. Pharmaceuticals (Basel). 2025;18(2):138.
  2. Zhou DD et al. Subcell Biochem. 2024;107:183-203.
  3. Li YR et al. Biofactors. 2018;44(1):69-82.
  4. Wood JG et al. Nature. 2004;430(7000):686-689.
  5. Kuršvietienė L et al. Medicina. 2016;52(3),148-155.
  6. Lakshminarasimhan M et al. Aging (Albany NY). 2013;5(3),151.
  7. Borra MT et al. J Biol Chem. 2005;280(17),17187-17195.
  8. Thaung Zaw JJ et al. Clin Nutr. 2021;40(3):820-829.
  9. Thaung Zaw JJ et al. Menopause. 2021;28(1):40-49.
  10. Wong RH et al. J Bone Miner Res. 2020;35(11):2121-2131.
  11. Thaung Zaw JJ et al. Nutrients. 2020;12(3):828.
  12. Chan EWC et al. J Appl Pharm Sci. 2019;9(7):124-129.
  13. Della Vedova L et a. Pharmaceuticals (Basel). 2025;18(2):138.
  14. Wang P, Sang S. Biofactors. 2018;44(1):16-25.
  15. Riche DM et al.  J Toxicol. 2013;2013:463595.
  16. Kapetanovic IM et al. Cancer Chemother Pharmacol. 2011;68(3):593-601.
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving %DV
Veri-te® Trans-Resveratrol 200 mg
Trans-Pterostilbene 50 mg
† Percent Daily Values (DV) not established

REV.10.25

Veri-te® is a registered trademark of the Lallemand group.
  • OTHER INGREDIENTS: Rice flour, hypromellose (capsule).
  • SUGGESTED DAILY USE: Take one (1) capsule per day with food.
  • CAUTION: For use by healthy adults only. Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place after opening.
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YWC
Natrona Heights, US
★★★★★ 1
Leather peels right off
Size: 8, Color: Black
Very poor quality - shoes are ruined after a couple months
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Reviewed in the United States on May 28, 2026
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David Dixon
Massapequa, US
★★★★★ 5
No Bending Required, No Hands Needed
Size: 12 Wide, Color: Cognac Napa Leather
The shoe is a good fit and run true to size, and color and quality are as advertised. Easy to slip on and off, without bending to do it.
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Reviewed in the United States on June 11, 2026
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LATASHA JORDAN
West Palm Beach, US
★★★★★ 5
Nice
Size: 9, Color: Black
Very comfortable. Worth the money
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Reviewed in the United States on June 1, 2026
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Blackqueen30
Whiting, US
★★★★★ 5
Good purchase
Size: 9.5, Color: Black
Value and quality was good
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Reviewed in the United States on May 16, 2026
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Amazon_Customer
Lake Worth, US
★★★★★ 5
The "Lazy Professional" Look: Is Hands-Free Luxury Actually Real?
Size: 9.5, Color: Black Napa Leather
Living down here in Florida, my footwear needs are pretty specific. It’s hot, it’s humid, and I spent half my life rushing from the car into work or a meeting. I’ve reached that age where I value efficiency just as much as style—maybe more. I’ve been eyeing the Marc Joseph New York Hands-Free Slip-on Penny Loafers for a while, and after putting them through the wringer, here is the honest truth from someone who just wants to look sharp without the hassle. The "Just Step-In" Reality Look, the big selling point here is the "Hands-Free" tech. We’ve all seen the commercials for those athletic slip-ins, but finding that in a legitimate leather penny loafer is a different game. Does it work? Yes, surprisingly well. The heel counter is firm enough that it doesn’t collapse when you slide your foot in, but it doesn’t feel like a piece of plastic digging into your Achilles once you’re in. For those of us who are tired of bending over or hunting for a shoehorn every morning, this is a genuine quality-of-life upgrade. The Florida Factor: Comfort and Style The leather is actual calfskin (on most models), which is a must for the Florida heat. Synthetic shoes turn into a sauna within ten minutes, but these breathe reasonably well. The aesthetic is classic—it’s a "professor" shoe through and through. You can wear them with chinos and a blazer for work or throw them on with some nice jeans for a weekend lunch. Inside, they’ve got a gel heel insert and a padded footbed. It’s not quite "walking on a cloud"—let’s not over-hype it—but it’s a massive step up from the hard, flat soles of traditional dress loafers. I’ve spent four hours on my feet lecturing, and my arches didn’t hate me by the end of the day. The Sizing Gamble Here’s where you need to be careful. The consensus from other guys (and my own experience) is that the sizing is a bit of a coin toss. They tend to run a little large and sometimes wide. If you have narrow feet, you might find the sides "gaping" or flaring out when you walk, which kills the sleek look. I’d recommend ordering a half-size down if you’re usually between sizes. The Breakdown The Pros: True Hands-Free: You can actually put these on while holding a coffee and a briefcase. No hands needed. Legit Materials: The calf leather feels premium and smells like the real deal. Versatility: Perfectly bridges the gap between a "car shoe" and a formal loafer. Comfort: The gel insert makes a noticeable difference for long-duration wear. The Cons: Sizing Inconsistency: They can run wide, leading to some "heel slip" if you don't get the perfect fit. Break-in Period: The heel is stiff by design (to allow for the slip-on feature), so expect a day or two of minor stiffness. Price Point: They aren't cheap, though often on sale. Value for Money Are they worth it? If you’re comparing them to high-end Italian brands that cost $500, these are an absolute steal. They look 90% as good for a fraction of the price. However, if you're used to $60 mall shoes, the jump to $150+ might feel steep until you realize you’re paying for the convenience of never having to touch your shoes to put them on. For a daily driver in a professional setting, the value is definitely there.
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Reviewed in the United States on April 10, 2026

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