SKU: 66885789638

CDS22-formula | The Original De Simone Formulation UK Probiotic (112B CFU) | 20 Cap Pack

$16.11 $17.90
Save 10%
No.2 Bestseller on salfueradeti.es >

Pay in installments of $4.47 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 29 - Sep 3

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

CDS22-formula | The Original De Simone Formulation UK Probiotic (112B CFU) | 20 Cap PackCDS22 formula is the original 8 strain De Simone Formulation, supplied as 20 vegetable capsules, with 112 billion live bacteria (CFU) in every capsule. It is the same formulation that was sold under the VSL#3 brand until 2016 and the Vivomixx brand in the EU and UK until 2025. The identity is carried by the eight strains and their NCIMB deposit codes, not by the brand name. Here is the documented history: Early 1990s De Simone Formulation developed by

CDS22-formula is the original 8-strain De Simone Formulation, supplied as 20 vegetable capsules, with 112 billion live bacteria (CFU) in every capsule.

It is the same formulation that was sold under the VSL#3 brand until 2016 and the Vivomixx brand in the EU and UK until 2025. The identity is carried by the eight strains and their NCIMB deposit codes, not by the brand name. Here is the documented history:

Early 1990s
De Simone Formulation developed by Professor Claudio De Simone — an 8-strain live bacteria mixture.
Until 2016
Sold under the VSL#3 brand (trademark of Actial Srl). Most older studies referencing "VSL#3" refer to this original formulation.
2016 – 2025
Sold as Vivomixx in the EU and UK (trademark of Mendes SA) and as Visbiome in the US and Canada. A US federal court found that products sold as VSL#3 after 2016 are a different formulation.
2025 – present
Supplied in the UK as CDS22-formula — the same 8-strain composition and NCIMB strain identity.

Trademark note: VSL#3® is a trademark of Actial Srl; Vivomixx® is a trademark of Mendes SA; Visbiome® is a trademark of ExeGi Pharma. CDS22-formula is independent of and not affiliated with, endorsed by, or distributed by these companies. Brand names above are stated as historical fact for identification only.

At a glance

  • Format: 20 vegetable (HPMC) capsules per pack
  • Live bacteria: 112 billion CFU per capsule, across 8 strains
  • Strain identity: 8 strains with NCIMB deposit codes (full list below)
  • Formulation: the De Simone Formulation (sold as VSL#3 until 2016, Vivomixx until 2025)
  • Suitable for: vegetarians · gluten-free · no preservatives or synthetic sweeteners
  • Storage: refrigerate +2°C to +8°C (stable to 25°C for up to one week)
  • Price & dispatch: £17.90 inc. VAT · cold-chain shipped from our Lancashire facility

Strain composition (per capsule)

Strain NCIMB code CFU per capsule
Streptococcus thermophilus NCIMB 30438 58 billion
Lactobacillus acidophilus NCIMB 30442 9 billion
Lactobacillus plantarum NCIMB 30437 9 billion
Lactobacillus paracasei NCIMB 30439 9 billion
Lactobacillus helveticus NCIMB 30440 9 billion
Bifidobacterium breve NCIMB 30441 6 billion
Bifidobacterium animalis subsp. lactis NCIMB 30435 6 billion
Bifidobacterium animalis subsp. lactis NCIMB 30436 6 billion
Total live bacteria per capsule 112 billion

Full ingredients: mixture of lactic ferments (the 8 strains listed above); bulking agent: microcrystalline cellulose; capsule shell: hydroxypropylmethylcellulose (vegetable); anti-caking agents: fatty acids, magnesium salts of fatty acids. Gluten-free. Contains no preservatives or synthetic sweeteners.

Key features

  • 112 billion CFU per capsule — 8 strains, each identified by its NCIMB deposit code
  • The original De Simone Formulation (sold as VSL#3 until 2016, Vivomixx until 2025)
  • Vegetable HPMC capsule — suitable for vegetarians; gluten-free
  • No preservatives and no synthetic sweeteners
  • Cold-chain handled and dispatched from our temperature-controlled Lancashire facility
  • Authorised UK distributor of CDS22-formula — UK dispatch, no import or customs charges

Cold-chain handling

This is a live-culture product. It is transported refrigerated from the manufacturer to our temperature-controlled facility in Lancashire and dispatched cold-chain protected to your door. Keep it refrigerated at +2°C to +8°C; it remains stable at room temperature (up to 25°C) for up to one week, which covers normal transit. See our cold-chain delivery information.

Choosing the right format

The 112 billion capsule is the everyday format. If you want a higher per-serving count or a non-capsule option, or you're buying for a child, these may suit better:

Background reading: What happened to Vivomixx in the UK? · VSL#3 alternative UK · De Simone Formulation reference

How to take

Adults: 1 to 4 capsules daily, preferably before meals, with water. Do not exceed the recommended daily dose. Keep refrigerated. Children's dosing is set out in the manufacturer Patient Information Sheet; for babies and young children see CDS22-formula Infant Drops.

This product is a food supplement. It is not intended to diagnose, treat, cure or prevent any disease or health condition. No authorised EU/UK health claim is made for CDS22-formula or its bacterial strains on this page. Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle.

Frequently asked questions

What is CDS22-formula?

CDS22-formula is a high-count, multi-strain live bacteria food supplement. Each vegetable capsule contains 112 billion CFU across 8 named strains, identified by their NCIMB strain codes. A pack contains 20 capsules. It is the current brand name for the De Simone Formulation, the 8-strain mixture sold as VSL#3 until 2016 and as Vivomixx until 2025.

Is CDS22-formula the same as Vivomixx?

CDS22-formula contains the same 8-strain De Simone Formulation, identified by the NCIMB strain codes on the label, that was sold under the Vivomixx brand in the EU and UK until 2025. Identity is best confirmed by the strain list rather than by brand name alone. Vivomixx is a registered trademark of Mendes SA. CDS22-formula is independent of and not affiliated with, endorsed by, or distributed by Mendes SA.

What happened to Vivomixx in the UK?

Vivomixx was the European and UK brand name for the De Simone Formulation from 2016. In 2025 the formulation was rebranded as CDS22-formula, which is the version now supplied in the UK. The 8-strain composition and NCIMB strain identity are unchanged. Vivomixx is a registered trademark of Mendes SA; no affiliation exists.

Is CDS22-formula a VSL#3 alternative?

The De Simone Formulation was sold under the VSL#3 brand until 2016. A US federal court found that products sold as VSL#3 after 2016 are a different formulation, produced by a separate party that we do not supply. CDS22-formula carries the original 8-strain De Simone Formulation. VSL#3 is a registered trademark of Actial Srl; CDS22-formula is not affiliated with it.

What is the De Simone Formulation?

The De Simone Formulation is an 8-strain live bacteria mixture developed by Professor Claudio De Simone in the early 1990s. It was sold under the VSL#3 brand until 2016, then under the Vivomixx brand in the EU and UK and the Visbiome brand in the US and Canada, and is supplied in the UK today as CDS22-formula. The strains are identified by NCIMB deposit codes.

Which strains are in CDS22-formula, and at what CFU?

Each capsule contains 112 billion CFU: Streptococcus thermophilus NCIMB 30438 (58 billion), Lactobacillus acidophilus NCIMB 30442 (9 billion), Lactobacillus plantarum NCIMB 30437 (9 billion), Lactobacillus paracasei NCIMB 30439 (9 billion), Lactobacillus helveticus NCIMB 30440 (9 billion), Bifidobacterium breve NCIMB 30441 (6 billion), and Bifidobacterium animalis subsp. lactis NCIMB 30435 and NCIMB 30436 (6 billion each).

Is CDS22-formula suitable for vegetarians?

Yes. The capsule shell is hydroxypropylmethylcellulose (HPMC), a vegetable capsule, so the product is suitable for vegetarians. It is also gluten-free and contains no preservatives or synthetic sweeteners.

Why does CDS22-formula need to be kept refrigerated?

CDS22-formula contains live bacteria, and refrigeration at +2°C to +8°C maintains the stated count over the product's shelf life. It stays stable at room temperature up to 25°C for up to one week, which covers transit. We ship it cold-chain protected from our temperature-controlled Lancashire facility.

How many capsules are in a pack and how do I take them?

A pack contains 20 vegetable capsules. The manufacturer direction for adults is 1 to 4 capsules daily, preferably before meals, taken with water. Do not exceed the recommended daily dose. Keep refrigerated.

How is CDS22-formula delivered in the UK?

Orders are dispatched cold-chain protected from our temperature-controlled facility in Lancashire via Royal Mail 24 or DPD, to all of the UK including Northern Ireland. Because it ships within the UK, there are no import or customs charges.

Product details: CDS22-formula · 20 vegetable (HPMC) capsules · 112 billion CFU per capsule · 8 strains with NCIMB codes · the original De Simone Formulation · authorised UK distributor of CDS22-formula · £17.90 inc. 20% VAT.

Advisory information (UK): Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, taking any medication or under medical supervision, consult a doctor or pharmacist before use. If you experience any adverse reaction, stop use and seek medical advice. Keep out of the reach of young children. Do not use if the seal under the cap is broken or missing. Do not exceed the stated recommended daily dose. This product is a food supplement and is not a medicine. Regulated for sale in the UK under the FSA; for health information the NHS is the appropriate reference.

VSL#3® is a registered trademark of Actial Srl. Vivomixx® is a registered trademark of Mendes SA. Visbiome® is a registered trademark of ExeGi Pharma. CDS22-formula is not affiliated with, endorsed by, or distributed by these companies. Historical brand names are used for identification and factual continuity only.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 66885789638

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.5 ★★★★★
Based on 20 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
S
Verified Purchase
Susan Thompson
Lexington, US
★★★★★ 5
Great Buy
Color: Gold
Very heavy duty! Also classy and matches my gold faucet perfectly. Great value!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 26, 2026
A
Amazon Customer
Dallas, US
★★★★★ 4
Feels like a real upgrade, but maybe priced a little high
Color: Stainless Steel
This is one of those things you don’t think much about until you switch to a better one. Right away you notice the weight. It actually stays put when you pull a sheet instead of sliding all over the counter or tipping up, which already makes it better than most cheap holders. The spring arm does help keep the roll under control so you’re not pulling half the roll by accident. One handed use works most of the time, but it depends on the paper towels. Thinner rolls tear clean without any effort. Thicker ones can still need a second hand here and there, so it’s not perfect but still better than a basic stand. Build quality feels solid. The finish looks clean and not cheap, and it wipes down easily. It definitely looks like something you’d keep out on the counter instead of hiding. Only real downside is the price. It does what it’s supposed to do and does it well, but it’s still a paper towel holder at the end of the day. You’re paying for the weight and design more than anything. If you’re tired of flimsy ones, this is a noticeable step up. Just depends if you care enough to spend extra on something this simple.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 2, 2026
L
LovelyHaze♡Peace & Love
Natrona Heights, US
★★★★★ 5
Sleek Kitchen Essential One Handed Paper Towel Dispenser
Color: Black, Color: Black
​The Ultrean paper towel holder is a countertop accessory designed for convenience featuring a sturdy stainless steel construction that wipes clean easily and blends into any kitchen or bathroom decor. It stands upright on a weighted non slip base that provides stability during use and it is equipped with a spring loaded arm intended to assist with one handed tearing. The assembly is very straightforward making it quick to set up right out of the box so you can start using it immediately for your daily cleaning tasks. ​I found this holder very easy to put together and integrate into my space and it definitely adds a nice modern touch to my kitchen counters. While it is marketed as a one handed tear dispenser I have noticed that it depends on the type of paper towels you are using. If I am using thinner cheaper rolls the tear is effortless but with my preferred thick Bounty paper towels the tension is not always enough to tear them off cleanly with just one hand so I usually end up holding it down to get a clean rip. ​The major pros of this dispenser are the weighted non slip base that keeps it from sliding around and the stainless steel finish that makes maintenance simple with just a quick wipe. The main con is that it struggles with heavy duty paper towels often requiring two hands to tear without tipping or pulling the whole roll which might be frustrating if you are expecting a true one handed experience every single time. Still it is a functional and attractive piece that keeps my kitchen organized and as long as you do not mind using both hands for the thicker brands it is a solid addition to any home.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 25, 2026
B
Billy
Cuba, US
★★★★★ 5
A Paper Towel Holder That Actually Holds Its Own
Color: Gold
This is a lot nicer than I expected for something as boring as a paper towel holder. The base has some real weight to it, so it doesn’t slide around every time you try to tear off a sheet. The spring-loaded arm also helps keep the roll from spinning freely. The gold finish looks good in person. It leans a little more bronze/brassy than bright gold, which my wife prefers in our darker colored kitchen. It feels sturdy, wipes clean easily, and doesn’t look cheap sitting on the counter. The one-handed tearing works pretty well, though it may depend on the paper towels you use. Thinner rolls tear off easily. With thicker paper towels, you may still need a second hand here and there to get a clean rip. We use the Costco branded Kirkland paper towel rolls and haven't had any issues getting just one sheet. I am guilty of yanking at our old paper towel with one hand roll to try and rip off a single sheet. My success rate has significantly increased since we started using this paper towel holder. It’s definitely more expensive than a basic paper towel holder, but it also feels like a clear upgrade from the cheap flimsy ones. Would I normally buy this? Probably not, but if I am splurging on kitchen upgrades, then I'd definitely have this on my list.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 12, 2026
E
Eva
Massapequa, US
★★★★★ 5
Pretty gold tone color and works well
Color: Gold
This is great for lazy people like myself. Just pull back the grabber hand and drop the paper towels in, no unscrewing anything or fiddling around, I only want to spend one second installing my paper towels and this lets me do that. The gold tone works well with my decor, it has a very finely brushed gold tone metal finish trending into brass color tones that looks better in person than in the listing. Overall it looks very high end. The bottom is very heavily weighted, paper towels slip right on, and removing a towel with one hand is a snap. The grabber hand keeps the towels in place. On the bottom are 4 very effective grabby strips that keep the unit from sliding. The whole unit weighs 3 pounds but somehow it seems like it's a lot more. Checking over the listing, it looks accurate other than some of the photos make it look a little less golden than it really is. This thing is so nice. I was going to use this at work but it might be too nice looking for an industrial environment so I'll probably just use it at home instead. The downsides on this are there were a few super tiny scratches that you'd really have to squint to see. You probably would not notice but still not ideal. The other obvious issue is these are currently priced at $50. Looking around at other options, I don't see many with all the features of this unit including upscaled finish, smoothly operating grabby hand, and heavily weighted bottom but certainly there are many other towel holder options that get good reviews for less money so I would not say this unit is the best economic bang for the buck. However if you really don't care about an extra $20 or you would really like an upscale nice brushed gold/brass finish, then it might be well worth it for you because this does work really well and I am very much enjoying it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 18, 2026

recommand products

TECHNO KING ICED SET RAPPER 14K GOLD WATCH CUBAN BRACELET RING SET L013
69.99
Rolex Sea-Dweller 43 Stainless Steel 126600 50th Anniversary 2021 Model
6139.48
denver-018221a-ivory-blue 80x150
46.00
Rolex Explorer II 226570 White Polar Dial Stainless Steel 2026
8950.00
Vacuum Pump Standard Motor Parts VCP152
659.05