SKU: 37289196452

Aliye Bricker, M.D.

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Description

Aliye Bricker, M.D.RETpositives founder, our North Star, passed away from Stage IV NSCLC in February 2022. She was deeply committed to finding next generation RET therapies. We continue the fight in her honor and all of our fellow RET warriors as we work together to make RET altered cancer just another chronic disease. "I was already stage IV by the time I was diagnosed in late 2015. I was a 34 year old never smoker with a 4 year old, pregnant with my second daughter

RETpositive’s founder, our North Star, passed away from Stage IV NSCLC in February 2022. She was deeply committed to finding next generation RET therapies. We continue the fight in her honor and all of our fellow RET warriors as we work together to make RET-altered cancer just another chronic disease.

"I was already stage IV by the time I was diagnosed in late 2015. I was a 34-year-old never-smoker with a 4-year-old, pregnant with my second daughter while still working as a full-time physician (Neuroradiologist). When I developed a dry, nagging cough in the last few weeks of my pregnancy, my Obstetrician and I wanted to wait until the delivery to get a chest X-ray to avoid any radiation to my unborn baby. The day after my delivery, my chest X-Ray showed a lung mass and pleural effusions, and I was put on antibiotics for presumed pneumonia (even though I never had a fever). Five days later my effusion was drained, leading to my diagnosis with NSCLC. It had already spread to my brain and bones. This terminal diagnosis came as a complete shock. A quick google search informed me that my chances of being alive in five years were about 1%.

"I started off my maternity leave with gamma knife to my solitary brain metastasis and I started chemotherapy (Carboplatin plus Alimta) right away. I had a pleurex catheter placed for my recurrent effusions which came out eight months later. Luckily for me, my oncologist sent my tumor sample for genetic testing and a RET driver mutation was found. Although there were no RET-targeted treatments at the time of my diagnosis, finding RET was still a source of hope.

"After first-line chemotherapy stopped working, I tried (and failed) immunotherapy,  tried (and failed) one of the earlier multikinase inhibitors (cabozantinib), and I developed liver mets to add to my collection, before losing all of my hair with second-line chemotherapy (Docetaxol plus carboplatin.) By the end of the summer in 2017, I was bald and entirely dependent on oxygen, even at rest, and nearly out of treatment options. When the Selpercatinib trial opened at my institution, the Cleveland Clinic, in September 2017 I was the first to enroll, and within three weeks I was no longer oxygen-dependent. This first-generation RET-targeting tyrosene kinase inhibitor (TKI) gave me my life back and by that October, I was trick-or-treating with my kids (without any supplemental oxygen!).

"I’ve now been on Selpercatinib (Retevmo) for 3.5+ years and counting, and have experienced first-hand that medical research does save lives. Most recently in December 2020 my scans did show some small pleural lesions and a nodule in my lung that have been very slowly progressing, for which I underwent stereotactic radiation in January 2021. Most recent scans were encouraging, and I've learned how important it is to take everything one day at a time. My daughters are now five- and ten-years-old and I'm thankful for every day!"

 

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SKU: 37289196452

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4.1 ★★★★★
Based on 17 reviews
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Verified Purchase
BB #45
San Leandro, US
★★★★★ 5
Best collar for hunting.
Style: Alpha TT 25
My dog uses this everyday. Nothing beats this collar for location, and training. This is the best collar for hunting.
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Reviewed in the United States on January 9, 2026
R
Verified Purchase
Rebecca Nipper
Pawtucket, US
★★★★★ 5
Very pleased
Style: Alpha TT 25
My husband uses his garmin collar all the time. Works great and holds charge for several hours. He is very pleased with tracking distance.
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Reviewed in the United States on August 27, 2025
S
Verified Purchase
Stephen H.
Los Angeles, US
★★★★★ 5
Links up easily
Style: Alpha TT 25
Love it and love the new charger connection
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Reviewed in the United States on April 18, 2026
M
Verified Purchase
Mitch
Alexandria, US
★★★★★ 5
Adaptable to any dog
Style: Alpha TT 25
Fully scaleable from antenna to GPS unit. Holds charge well and durable. Could be cheaper.
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Reviewed in the United States on November 16, 2025
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Verified Purchase
toadskipper
Alexandria, US
★★★★★ 1
Garmin has been a super disappointment.
Style: Alpha TT 25
FOR THE REMOTE: For reasons I cannot fathom as a software developer, the Garmin developers chose to program the handheld to wait for GPS lock before allowing you to control the collar. This is stupid beyond belief and causes frustration that simply shouldn't be. Look Garmin, the remote should be able to communicate with the collar first and foremost. I want to be able to power everything up, put the collar on the dog, and walk out the door. If my dog sees a rabbit or deer, I want to be able to remind him not to chase. I DON'T want to stand there staring at my remote greeted by the message "Waiting for GPS" with all the buttons non-responsive. Fix this! This should be super easy to fix with a firmware update. Fix it and I'll gladly give this unit 10 stars! GPS is way too finicky to have to wait for it before using the basic controls. Update: SERIOUSLY!! HOT GARBAGE. This remote couldn't find a satellite if I stuck one up its... AGH.. and you can't communicate with your dog's collar until it does. FOR THE COLLAR: You won't be happy with the beeper.. It's super quiet. The light is an awesome feature. Vibration may work for your dog, mine doesn't seem to notice it at all. If the antenna was any longer it would pick up signals from outer space. Buy the shorter one if you decide to go with this unit and don't need to keep your dog from crossing an ocean. Seriously though... I'll never buy anything Garmin again. I would recommend you don't either.
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Reviewed in the United States on March 19, 2026

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