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Description
Alexa Fluor® 647 Mouse Anti-Rat CD71 Antibody (S-R638)Product Specification Host Mouse Antigen CD71 Synonyms Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; Tfrc Location Cell membrane Accession Q99376 Clone Number S R638 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Rt Positive Sample SD Rat bone marrow Purification Protein A Concentration 0. 05mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3% Proclin 300 Stability &
Product Specification
| Host | Mouse |
| Antigen | CD71 |
| Synonyms | Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; Tfrc |
| Location | Cell membrane |
| Accession | Q99376 |
| Clone Number | S-R638 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | SD Rat bone marrow |
| Purification | Protein A |
| Concentration | 0.05mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Rt |
Background
CD71, also known as transferrin receptor 1 (TfR1), is a type II transmembrane glycoprotein that exists as a disulfide-linked homodimer on the cell surface. It plays a crucial role in cellular iron uptake by binding to iron-bound transferrin and mediating its internalization through receptor-mediated endocytosis. CD71 is widely expressed on proliferating cells, including erythroid precursors, activated immune cells, and various cancer cells. It is also a preferred entry receptor for several viruses, such as arenaviruses and hepatitis C virus. In addition, CD71 has been identified as a marker for cell proliferation and activation, and its expression is often used in the diagnosis and prognosis of hematological diseases.
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