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Description
FTH1 Recombinant Rabbit mAb (S-1372-136)Product Specification Host Rabbit Antigen FTH1 Synonyms Ferritin heavy chain; Ferritin H subunit; Cell proliferation inducing gene 15 protein; FTH; FTHL6 Immunogen Synthetic Peptide Location Cytoplasm, Lysosome Accession P02794 Clone Number S 1372 136 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample MCF7, HeLa, HT 29, Jurkat, HepG2 Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | FTH1 |
| Synonyms | Ferritin heavy chain; Ferritin H subunit; Cell proliferation-inducing gene 15 protein; FTH; FTHL6 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Lysosome |
| Accession | P02794 |
| Clone Number | S-1372-136 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | MCF7, HeLa, HT-29, Jurkat, HepG2 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
FTH1, also known as Ferritin Heavy Chain 1, is a protein-coding gene that plays a crucial role in iron metabolism. It encodes a subunit of ferritin, the major intracellular iron storage protein in both prokaryotic and eukaryotic organisms. The ferritin protein is composed of 24 subunits of heavy and light chains, with FTH1 being the heavy chain component. This protein helps catalyze the oxidation of Fe²⁺ to Fe³⁺, facilitating iron storage in a soluble and non-toxic form. Additionally, FTH1 possesses ferrous iron binding activity and is involved in various biological processes, including immune response, cell proliferation, and protection against oxidative stress. Defects in the FTH1 gene are associated with several diseases, such as neurodegenerative disorders and iron overload conditions like Hemochromatosis Type 5.
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4.4 ★★★★★
Based on 20 reviews
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Product Reviews
★★★★★ 5
If Batman #666 is canon, then this collection is important.
I just read this Batman collection again and found a much greater appreciation for these stories than I did the first time around (not that they were all that bad to begin with).
Of course, Grant Morrison's run on Batman has gone on another two years since Batman & Son, so reading this now allows you to put some added perspective on what's going on here. First of all, you have the introduction of Batman's son, Damien (this is not a spoiler, isn't it pretty obvious from the title?), who has since already gone on to a larger role in the DC Universe. I think some important take-aways from these initial issues of Grant Morrison's run are Damien's origins and his character/attitude. I believe that Damien's character is going to have a big impact on what happens with Batman (and Dick Grayson) in the near future.
You also get a pretty unique Joker story, primarily told in text form. I really think Morrison shines in this kind of story-telling medium.
Additionally, if you pay attention, there are definitely some clues in Batman & Son that foreshadow the next events in Morrison's saga.
Lastly, there is issue #666. I don't want to give anything away about the story, but I have heard that Grant Morrison considers this to be part of the Batman canon (meaning that it is authentic to the whole Batman universe). If so, then in addition to the story, there are some particular frames that I think are going to be meaningful down the road For example, the one with Damien mourning over a Batman body and also the one from Damien's memory, showing three Bat-folk fighting crime together in the future.
Overall, I have become very pleased with Grant Morrison's work on this title. Of the comics that I currently follow, he is surpassing them all in excellence, even beyond what Ed Brubaker is doing with Captain America. Once you read this collection, you will certainly want to go on to the next one.. Batman: The Black Glove.
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Reviewed in the United States on January 27, 2010
★★★★★ 5
A comic pro weighs in
Everything was crisp about this story arc, and it certainly was a twist over others in the series... Batman had a son ! Who knew ?! The art was great (even though I don't go in for the computerized age LOL), and they characterizations were bold. I do think that 1 more story or additional pages were needed to set up this story a slight bit better, as I hate flashbacks that add history that are 'made up' on the spot. DC should've have authorized a new story, exclusive to this volume, with background detail with forethought to the plot. Overall A+ (but for Batman, anything less than A++ is suspicious).
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Reviewed in the United States on September 8, 2009
★★★★★ 4
Seriously? His name is Damien?
Morrison redeems himself in his Batman writing. I was a huge fan of All Star Superman, and thought his take on the Man of Steel was pure genius and very heart-warming, but his other work has been a bit of a disappointment to me. Final Crisis was pure drivel, and maybe there was a lot lost in the editing and compiling of such a massive cross-title story, but the dialogue left much to be desired as well.
Batman and Son certainly has an intriguing premise. Set before the "death" of Bruce Wayne and his nearly two year disappearance after Final Crisis, Batman and Son initiates a series of changes in the Bat-world that no doubt frustrated and angered die-hard fans. Bruce, has a son, Damian, who has been raised by his mother, the daughter of Ras Al'Ghul, who is plopped right back into his life at a time when Bruce is suffering a bit of an identity crisis, and boy does this complicate things. Damian is a 10 year old terror that matches his genetic and symbolic legacy.
What's brilliant: Morrison absolutely delivers in several key panels, especially toward the beginning of the book and some of the best dialogue is between Bruce and Alfred, especially over Alfred's concern that Bruce has forgotten to be anything, but Batman. In his words, "The growl and edge to your voice that you used to rehearse to put fear into criminals while wearing your costume never leaves when you take off the mask. It's like you've forgotten how to be anything but Batman." Part of what makes Bruce such an interesting character even after all of these years is that you're not really sure who he really is deep down inside. Is he really Batman pretending to be Bruce Wayne, or is he Bruce Wayne pretending to be Batman. You don't get that conflict with any other character in comics. Morrison also delivers on comedic relief with some hilarious scenes of Bruce, half-dressed as Batman learning to be a father and yelling at Damian (one imagines in the Batman growl) to go to his room.
Anywho, much, much better writing from Morrison, which I know he's capable of.
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Reviewed in the United States on July 24, 2011
★★★★★ 5
Where it all starts
If you buy this you are about to start reading the greatest Batman run since... let's just say this is the greatest run on Batman. I may be over hyping this, the story arcs collected here are good on their own, but until you read the next volume and return to this one, your not getting the whole story. So it's hard to say how great this story is, and how great it gets. I would only get this if you plan on buying the other 7 Morriosn Batman books that follow this. Black Glove, RIP, Batman Reborn, Batman vs Robin, Time and the Batman, Return of Bruce Wayne, and Batman Must Die!. In that order.
You'll have fun reading this run.
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Reviewed in the United States on September 21, 2010
★★★★★ 5
Visionary
If you're familiar with the work of Grant Morrison than you'll know this book was never intended to be read as a stand alone work. This is just the first few stories in a long run that culminate in Batman Inc. So, keep that in mind if you plan to jump on here. It's all or nothing.
I'm always amazed with Morrison's ability to craft smart, universe encapsulating, severely polarizing stories in almost every one of his runs. His meticulous plotting, spot on characterization, and willingness to take chances are just three of the plethora of reasons to buy this book.
If you like to be rewarded for paying attention and are looking for something more from your comics than "monster-of-the-week" this is for you.
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Reviewed in the United States on February 5, 2013