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Description
Biotin Mouse Anti-Human CD3ε Antibody (S-R531)Product Specification Host Mouse Antigen CD3 Synonyms T cell surface glycoprotein CD3 epsilon chain; T cell surface antigen T3 Leu 4 epsilon chain; T3E; CD3E Location Cell membrane Accession P07766 Clone Number S R531 Antibody Type Mouse mAb Isotype IgG2a Application FCM Reactivity Hu Positive Sample human peripheral blood lymphocytes Predicted Reactivity Gor, Pr, Cz, Or, Bv, Sh, Rt, Ct, Rb, Dg, De, Hdg, Bb, Hr, Ms Purification Protein A Concentration
Product Specification
| Host | Mouse |
| Antigen | CD3ε |
| Synonyms | T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; T3E; CD3E |
| Location | Cell membrane |
| Accession | P07766 |
| Clone Number | S-R531 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood lymphocytes |
| Predicted Reactivity | Gor, Pr, Cz, Or, Bv, Sh, Rt, Ct, Rb, Dg, De, Hdg, Bb, Hr, Ms |
| Purification | Protein A |
| Concentration | 0.02mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD3ε is a subunit of the CD3 complex, which is a critical component of the T-cell receptor (TCR) complex on T cells. Together with CD3γ, CD3δ, and CD3ζ, it forms the TCR-CD3 complex that plays a vital role in coupling antigen recognition to intracellular signaling pathways. This complex is essential for T cell activation, proliferation, and differentiation. CD3ε contains an extracellular immunoglobulin domain, a transmembrane region, and a cytoplasmic tail with an immunoreceptor tyrosine-based activation motif (ITAM). Upon antigen recognition, the ITAMs in CD3ε are phosphorylated, initiating downstream signaling cascades that lead to T cell activation. Additionally, CD3ε interacts with other signaling molecules like Lck and Nck through its unique motifs, further modulating T cell responses. Its importance in T cell function makes CD3ε a target for immunotherapies, including cancer treatments and autoimmune disease management.
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Exchange/Return Notes
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