Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 10 - Aug 15
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
CD25/IL-2Rα Recombinant Rabbit mAb (S-R223)Product Specification Host Rabbit Antigen CD25 IL 2R Synonyms Interleukin 2 receptor subunit alpha, IL 2 receptor subunit alpha, IL 2 RA, IL 2R subunit alpha, IL2 RA, TAC antigen, p55, IL2RA Location Membrane Accession P01589 Clone Number S R223 Antibody Type Recombinant mAb Application IHC P, ICC Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.
Product Specification
| Host | Rabbit |
| Antigen | CD25/IL-2Rα |
| Synonyms | Interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2-RA, TAC antigen, p55, IL2RA |
| Location | Membrane |
| Accession | P01589 |
| Clone Number | S-R223 |
| Antibody Type | Recombinant mAb |
| Application | IHC-P, ICC |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC | 1:500 | null |
| ICC | 1:500 | null |
Background
CD25 is expressed broadly among leukocytes. The highest surface expression of this protein is on regulatory T cells (Tregs), where CD25 is expressed constitutively, especially on a subset classified as naturally occurring Tregs. It can also be found on activated B cells, NK (natural killer) cells, thymocytes, and some myeloid lineage cells (e.g. macrophages, dendritic cells). L2RA has been used as a marker to identify CD4+FoxP3+ regulatory T cells in mice, and it has been found that a large proportion of resting memory T cells constitutively express IL2RA in humans. Levels of CD25 soluble form, called sIL-2Rα, has been connected to pathogenesis of autoimmune diseases and cancer. Since sCD25 is produced during immune activation, it is used as one of biomarkers to track disease progression and to indicate outcome for clinical disorders. Especially, it is a hallmark for hyper-activated immune system and cytokine storm, which may lead to multiple organ system failure.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy