Pay in installments of $45.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 13 - Aug 18
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
E-Cadherin Recombinant Rabbit mAb (Alexa Fluor® 647 Conjugate) (S-438-5)Product Specification Host Rabbit Antigen E Cadherin Synonyms Cadherin 1, CAM 120 80, Epithelial cadherin, Uvomorulin, CD324, Uvomorulin, L CAM Immunogen Recombinant Protein Location Cell membrane Accession P12830 Clone Number S 438 5 Antibody Type Recombinant mAb Isotype IgG Application IF Reactivity Hu, Ms, Rt Purification Protein A Concentration 2. 5 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 0. 1% BSA, 0. 01%
Product Specification
| Host | Rabbit |
| Antigen | E-Cadherin |
| Synonyms | Cadherin-1, CAM 120/80, Epithelial cadherin, Uvomorulin, CD324, Uvomorulin, L-CAM |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P12830 |
| Clone Number | S-438-5 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IF |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 2.5 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 0.1% BSA, 0.01% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| IF | 1:50-200 | null |
Background
E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by sequestering β-catenin from its binding to LEF (Lymphoid enhancer factor)/TCF (T cell factor) which serves the function of transcribing genes of the proliferative Wnt signaling pathway. Despite the ongoing debate on whether the loss of E-cadherin is the cause or effect of epithelial-mesenchymal transition (EMT), E-cadherin functional loss has frequently been associated with poor prognosis and survival in patients of various cancers. The dysregulation of E-cadherin expression that leads to carcinogenesis happens mostly at the epigenetic level but there are cases of genetic alterations as well. E-cadherin expression has been linked to the cellular functions of invasiveness reduction, growth inhibition, apoptosis, cell cycle arrest and differentiation.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy