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Description
IL-4 Protein, MouseProduct Specification Species Mouse Synonyms Interleukin 4,IL 4,B cell IgG differentiation factor,B cell growth factor 1,B cell stimulatory factor 1 (BSF 1),IGG1 induction factor,Lymphocyte stimulatory factor 1, Accession P07750 Amino Acid Sequence His23 Ser140 Expression System HEK293 Molecular Weight 17 20 kDa (Reducing) Purity >95% by SDS PAGE. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage
Product Specification
| Species | Mouse |
| Synonyms | Interleukin-4,IL-4,B-cell IgG differentiation factor,B-cell growth factor 1,B-cell stimulatory factor 1 (BSF-1),IGG1 induction factor,Lymphocyte stimulatory factor 1, |
| Accession | P07750 |
| Amino Acid Sequence | His23-Ser140 |
| Expression System | HEK293 |
| Molecular Weight | 17-20 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Med Sci Monit. 2016 Jan 23:22:244-50. |
Background
Mouse Interleukin-4(IL-4) is a monomeric, Th2 cytokine that shows pleiotropic effects during immune responses. It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four α-helix structure. IL-4 exerts its effects through two receptor complexes, Participates in at least several B-cell activation processes as well as of other cell types. IL-4 is primarily expressed by Th2-biased CD4+T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG1 and IgE in mouse B cells, acquisition of the Th2 phenotype by CD4+T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL-4 plays a dominant role in the development of allergic inflammation and asthma. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
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