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Description
Human ICAM2/CD102 Protein, His TagProduct Specification Species Human Synonyms Intercellular adhesion molecule 2, ICAM 2 Accession P13598 Amino Acid Sequence Protein sequence (P13598, Lys25 Gln223, with C His Tag) KVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGLETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQ Expression System HEK293 Molecular Weight Predicted MW: 23. 8 kDa Observed
Product Specification
| Species | Human |
| Synonyms | Intercellular adhesion molecule 2, ICAM-2 |
| Accession | P13598 |
| Amino Acid Sequence | Protein sequence (P13598, Lys25-Gln223, with C-His Tag) KVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGLETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQ |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 23.8 kDa Observed MW: 43-60 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
CD102, also known as Intercellular Adhesion Molecule-2 (ICAM-2), is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is constitutively expressed on endothelial cells, leukocytes, and platelets. As a ligand for the leukocyte integrin LFA-1 (αLβ2), CD102 plays a crucial role in mediating leukocyte adhesion, transmigration across the endothelium, and immune synapse formation during inflammation and immune responses. Its expression is less inducible by inflammatory cytokines compared to ICAM-1. CD102 is essential for lymphocyte homing and the recruitment of immune cells to sites of infection or injury, contributing to both innate and adaptive immunity.
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