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Description
TIM-3/HAVCR2 Fc Chimera Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms TIM3, HAVCR2, TIMD3, FLJ14428, KIM3 Accession G7P6Q7 Amino Acid Sequence Ser22 Arg201, with C terminal Human IgG1 Fc Expression System HEK293 Molecular Weight 60 72kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water
Product Specification
| Species | Cynomolgus |
| Synonyms | TIM3, HAVCR2, TIMD3, FLJ14428, KIM3 |
| Accession | G7P6Q7 |
| Amino Acid Sequence | Ser22-Arg201, with C-terminal Human IgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 60-72kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Kane L P. (2010) T cell Ig and mucin domain proteins and immunity. J Immunol. 184(6): 2743-2749. 2、Freeman G J. et al. (2010) TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol Rev. 235(1): 172-189. 3、Zhu C. et al. (2011) TIM-3 and its regulatory role in immune responses. Curr Top Microbiol Immunol. 350: 1-15. 4、Han G. et al. (2013) Tim-3: An Activation Marker and Activation Limiter of Innate Immune Cells. Front Immunol. 4: 449. |
Background
Tim-3 proteins are members of the T cell immunoglobulin and mucin domain (Tim) family, which contains a group of type I transmembrane proteins expressed by innate and adaptive cell types within the immune system. In humans and other mammals, the Tim family consists of three proteins (TIM-1, -3, and -4). The signature feature of Tim proteins is the extracellular domain, which consists of an N-terminal immunoglobulin variable region-like (IgV) domain containing approximately 100 amino acids and a serine/threonine-rich mucinoid domain of varying lengths containing target sites for O- and N- binding glycosylation. To date, the IgV domain of Tim-3 has been shown to interact with phosphatidylserine, the alarm protein HMGB1 (high mobility frame 1), and galactosin-9 displayed on apoptotic cell surfaces, a widely expressed soluble protein that is specific to carbohydrate chains containing beta-galactosidine sugars. Tim-3 binding to phosphatidylserine mediates uptake of apoptotic cells by phagocytes expressing Tim-35. Recent studies using human primary CD8 T cells have shown that Tim-3 is associated with immune synapses formed between CD8 T cells and target cells, and that Tim-3 colocalizes with phosphatases that inhibit T cell receptor (TCR) signaling.
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