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Description
SQLE Recombinant Rabbit mAb (S-2358-207)Product Specification Host Rabbit Antigen SQLE Synonyms Squalene monooxygenase; Squalene epoxidase (SE); ERG1 Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession Q14534 Clone Number S 2358 207 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Mk Positive Sample HEK 293, Raji, PC 3, A549, HepG2, F9, mouse testis Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | SQLE |
| Synonyms | Squalene monooxygenase; Squalene epoxidase (SE); ERG1 |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | Q14534 |
| Clone Number | S-2358-207 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Mk |
| Positive Sample | HEK-293, Raji, PC-3, A549, HepG2, F9, mouse testis |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:1000 | Hu, Ms |
| ICC | 1:500 | Hu |
Background
SQLE (squalene epoxidase or squalene monooxygenase) is a 64 kDa, 574-residue FAD-dependent endoplasmic-reticulum enzyme that catalyzes the stereospecific epoxidation of squalene to 2,3-oxidosqualene, the first committed oxygenation and second rate-limiting step of cholesterol biosynthesis; it comprises an N-terminal cholesterol-sensing regulatory domain that undergoes MARCH6-mediated ubiquitination and proteasomal degradation when membrane cholesterol is high, and a C-terminal catalytic domain that uses NADPH-cytochrome P450 reductase to transfer electrons for the reaction, while its own substrate squalene can bind the regulatory domain to suppress degradation, thus functioning as both feed-forward signal and metabolite, and because fungal SQLE is sufficiently divergent, selective inhibitors such as terbinafine block fungal ergosterol synthesis without affecting the human enzyme, making SQLE a validated antimicrobial target.
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