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Description
CCL1/I-309 Protein, HumanProduct Specification Species Human Synonyms C C motif chemokine 1, Small inducible cytokine A1, T lymphocyte secreted protein I 309 Accession P22362 Amino Acid Sequence Lys24 Lys96 Expression System E. coli Molecular Weight 10 13 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according
Product Specification
| Species | Human |
| Synonyms | C-C motif chemokine 1, Small-inducible cytokine A1, T lymphocyte-secreted protein I-309 |
| Accession | P22362 |
| Amino Acid Sequence | Lys24-Lys96 |
| Expression System | E.coli |
| Molecular Weight | 10-13 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | J Exp Med. 2013 Jul 29;210(8):1509-28. |
Background
CCL1 (Chemokine (C-C motif) Ligand 1), also known as I-309 in humans and TCA-3 in mice, is a small glycoprotein belonging to the CC chemokine β-subfamily. Human CCL1 shares ~42% amino acid identity with mouse TCA-3; both contain a unique extra pair of cysteine residues not found in most other chemokines.
In scientific and industrial fields, CCL1 mainly is focused on CCR8-targeted immunotherapy. CCR8 is an attractive drug target due to its restricted expression pattern (primarily Tregs and Th2 cells) and single human ligand (CCL1), minimizing off-target effects. CCL1 levels are also elevated in bronchoalveolar lavage of asthmatic patients and serum of atopic dermatitis patients .
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