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Description
NOTCH2 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms NOTCH2, hN2, N2ECD Accession Q04721 Amino Acid Sequence Leu26 Gln530, with C terminal hIgG1 Fc Expression System HEK293 Molecular Weight 85 93kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation.
Product Specification
| Species | Human |
| Synonyms | NOTCH2, hN2, N2ECD |
| Accession | Q04721 |
| Amino Acid Sequence | Leu26-Gln530, with C-terminal hIgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 85-93kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Gene ID: 4853, updated on 12-Dec-2023. |
Background
Human Notch-2 is a 300 kDa type I transmembrane glycoprotein. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of developmental processes by controlling cell fate decisions. As a receptor for the membrane-binding ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1), the ligands, activated by the released notch intracellular domain (NICD), form a transcription activator complex with RBPJ/RBPSUH to activate the division site enhancer gene.
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