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Description
CSF-1R Recombinant Rabbit mAb (S-467-26)Product Specification Host Rabbit Antigen CSF 1R Synonyms Macrophage colony stimulating factor 1 receptor, CSF 1 receptor, CSF 1 R, M CSF R, Proto oncogene c Fms, CD115, FMS Immunogen Synthetic Peptide Location Cell membrane Accession P07333 Clone Number S 467 26 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Predicted Reactivity Ct Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | CSF-1R |
| Synonyms | Macrophage colony-stimulating factor 1 receptor, CSF-1 receptor, CSF-1-R, M-CSF-R, Proto-oncogene c-Fms, CD115, FMS |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P07333 |
| Clone Number | S-467-26 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Ct |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | |
| IHC-P | 1:100 |
Background
Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded by the human CSF1R gene (known also as c-FMS). CSF1R is a receptor that can be activated by two ligands: colony stimulating factor 1 (CSF-1) and interleukin-34 (IL-34). CSF1R is highly expressed in myeloid cells, and CSF1R signaling is necessary for the survival, proliferation, and differentiation of many myeloid cell types in vivo and in vitro. CSF1R signaling is involved in many diseases and is targeted in therapies for cancer, neurodegeneration, and inflammatory bone diseases.
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