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Description
Alexa Fluor® 647 Rat Anti-Mouse/Human CD324 Antibody (S-R650)Product Specification Host Rat Antigen CD324 Synonyms Cadherin 1; CAM 120 80; Epithelial cadherin (E cadherin); Uvomorulin; CDHE; UVO; CDH1 Location Cytoplasm, Endosome, Cell membrane Accession P12830 Clone Number S R650 Antibody Type Rat mAb Isotype IgG1,k Application FCM Reactivity Ms Positive Sample HT 29 Purification Protein G Concentration 0. 05mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA,
Product Specification
| Host | Rat |
| Antigen | CD324 |
| Synonyms | Cadherin-1; CAM 120/80; Epithelial cadherin (E-cadherin); Uvomorulin; CDHE; UVO; CDH1 |
| Location | Cytoplasm, Endosome, Cell membrane |
| Accession | P12830 |
| Clone Number | S-R650 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | HT-29 |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu, Ms |
Background
CD324, also known as E-cadherin or cadherin-1, is a calcium-dependent cell adhesion protein that plays a crucial role in maintaining epithelial tissue integrity and regulating cell proliferation, differentiation, and survival. It is a member of the cadherin superfamily and is widely expressed on the cell surface of most epithelial tissues. The extracellular domain of CD324 facilitates homophilic binding between adjacent cells, while its cytoplasmic domain interacts with the actin cytoskeleton through catenins. This protein is essential for epithelial cell cohesion and acts as an invasion suppressor, with its loss often indicating high tumor aggressiveness in cancer.
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